侵袭性感染的风险因素和结果在患者中殖民的Candidozyma auris:一个病例对照研究
Shuroug A Alowais1,2,3, Haytham A Wali4, Khalid Bin Saleh1,2,3
1College of Pharmacy, King Saud bin Abdulaziz University for Health Sciences, Riyadh 14611, Saudi Arabia.
Antibiotics (Basel, Switzerland)
|December 30, 2025
概括
大约13%的患有Candida auris殖民的患者发生了感染. 最近的腹部手术是进展的关键预测因素,导致死亡率更高.
科学领域:
- 传染性疾病 传染性疾病
- 临床微生物学 临床微生物学
- 流行病学 流行病学
背景情况:
- 黄是一种具有高殖民率的全球多药耐药病原体.
- 对于从殖民到侵入性感染的过渡和相关结果的理解有限.
- 这项研究研究了C.的风险因素. 在被殖民的患者中感染的进展.
研究的目的:
- 描述C的特征和结果. 艾瑞斯 - - 殖民患者.
- 识别预测从殖民到感染的进展的风险因素.
- 分析与C.死亡率相关的因素. 患有Auris感染的患者.
主要方法:
- 在一个单一的三级保健中心 (2018-2024) 进行了回顾性病例控制研究.
- 在殖民和感染患者之间比较人口统计,并发病,器械使用和先前的抗菌药物暴露.
- 多变量分析确定了感染进展的独立预测因素.
主要成果:
- 在334名殖民患者中,13.2%的病例进展为感染.
- 感染组具有较高的并发症指数,中线,机械通风,腹腔营养和腹部手术率.
- 腹部手术是感染的唯一独立预测因素 (OR 4.08).
- 感染组的住院死亡率明显高于感染组 (65.9%对33.1%).
结论:
- 大约八分之一的C. 艾瑞斯殖民的患者进展到感染.
- 最近的腹部手术独立预测到C.的进展. 病毒感染. 病毒感染.
- 在C.I.C.中, 耳炎感染与死亡率增加和住院时间延长有关,需要有针对性的预防策略.
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