在生产的动物料中多重检测兽药:一篇评论
Ana Lúcia Lopes1,2, Marta Leite2,3, Maria Beatriz P P Oliveira1,3
1Faculty of Pharmacy, University of Porto, Rua de Jorge Viterbo Ferreira 228, 4050-313 Porto, Portugal.
Antibiotics (Basel, Switzerland)
|December 30, 2025
概括
开发一种用于动物料中的兽医抗生素的多重检测方法对于食品安全和减少抗菌素耐药性至关重要. 本研究审查了确保料符合欧洲法规,保护消费者的方法.
科学领域:
- 食品安全和兽医 动物医学
- 分析化学 分析化学
- 监管合规性 监管合规性
背景情况:
- 不适当地使用兽药,特别是动物料中低于治疗水平的抗生素,对食品安全构成风险,并促进抗菌素耐药性.
- 确保遵守欧盟委员会关于动物料的法规对于消费者保护和全球健康至关重要.
研究的目的:
- 对动物料中的抗生素有效的多重检测方法进行审查和建立基础.
- 确保动物料符合欧盟法规,保护消费者健康和打击抗菌素耐药性.
主要方法:
- 在主要的科学数据库 (PubMed,ScienceDirect,Scopus,Google Scholar) 进行了全面的文献搜索,并审查了欧盟法规.
- 分析了各种溶剂,提取技术 (例如SPE,d-SPE,LLE,QuEChERS) 和净化步骤.
- 确定液体染色学与质谱学相结合,作为多重检测的首选分析技术.
主要成果:
- 常见的溶剂包括甲醇,乙二和超纯水,通常与酸或合剂结合用于提取.
- 评估了多种提取和净化策略,包括固相提取和蛋白质沉.
- 与质谱学 (LC-MS) 结合的液体染色学被强调为同时检测多种抗生素的最佳方法.
结论:
- 审查的数据支持开发一种可靠的方法,用于从动物料中同时提取多个类别的抗生素.
- 拟议的方法适用于各种生产食品动物的料,加强监管控制和消费者安全.
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