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相关概念视频

Overview of Transposition and Recombination02:13

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Transposons make up a significant part of genomes of various organisms. Therefore, it is believed that transposition played a major evolutionary role in speciation by changing genome sizes and modifying gene expression patterns. For example, in bacteria, transposition can lead to conferring antibiotic resistance. Movement of transposable elements within the genetic pool of pathogenic bacteria can aid in transfer of antibiotic-resistant genetic elements. In eukaryotes, transposons can carry out...
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The first successfully cloned mammal was Dolly, a sheep, born on 5th July 1996 at Roslin Institute, Scotland. The cloned sheep was named after the American singer Dolly Parton. Dolly lived for seven years and died of respiratory complications, which is speculated to be due to the actual age of her DNA. Because the DNA in cloned cells belongs to an older individual,  the cloned individual’s life expectancy may be affected. Indeed, analysis of Dolly’s DNA revealed shorter...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
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可移植元素调节绵羊胎儿的尾巴发育和脂肪沉积.

Qianqian Liang1, Haichen Yang1, Huajiao Dong1

  • 1College of Animal Science and Technology, Shihezi University, Shihezi 832003, China.

Animals : an open access journal from MDPI
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PubMed
概括

可转移元素 (TE) 显著影响绵羊尾巴的发育,例如SINE/MIR,L1和BovB的特定元素表现出特定阶段的表达. 这些TEs与尾巴延长和脂肪沉积有关,为羊养殖提供了洞察力.

关键词:
在RNA-seqqq.胚胎发生是胚胎发生.羊的胎儿是羊的胎儿尾巴的发展 尾巴的发展可转移的元素可以转移.

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科学领域:

  • 基因组学就是基因组学.
  • 发育生物学 发展生物学
  • 分子进化分子进化

背景情况:

  • 可转移元素 (TE) 是移动的遗传序列,在各种生理过程中具有已知的作用.
  • 哺乳动物尾巴发育中的特E的具体功能尚未得到充分理解.
  • 了解 TE 调节对于破译发育机制至关重要.

研究的目的:

  • 调查羊尾巴发育过程中TEs的表达模式和调节作用.
  • 识别涉及关键发展阶段和过程的特定技术特征.
  • 提供关于绵羊尾巴表型的遗传基础的见解.

主要方法:

  • 用RNA测序 (RNA-seq) 来分析基因表达特征.
  • 使用TEtranscripts管道来识别和量化差异表达的TE.
  • 进行了生物信息分析,包括途径丰富,以将TE活性与基因表达和发育功能相关联.

主要成果:

  • 对于SINE/MIR,L1和BovB元素,观察到显著的特定阶段表达.
  • 在不同发育阶段确定了动态数量的差异表达的TE (2129和5554在特定阶段之间).
  • 位于基因间区域的TEs,内子和3'UTR显示出与邻近基因一致的表达趋势,涉及它们的尾巴延长和脂肪形成,特定的候选人被确定为脊椎形成和脂肪沉积.

结论:

  • 可转移的元素在绵羊尾巴发育中发挥着重要的,以前被低估的作用.
  • 特定的TEs是动态调节的,与关键的发育过程相关,如尾巴延长和脂肪沉积.
  • 这项研究提供了有价值的遗传信息,可以通过了解TE介导的特征变异来改善绵羊育种计划.