月经周期与前-上连接和延迟折扣的关联
Ming Yang1, Jiajia Xie2, Xiaofen An1
1School of Psychology and Cognitive Science, East China Normal University, Shanghai 200062, China.
Behavioral sciences (Basel, Switzerland)
|December 30, 2025
概括
卵巢激素,特别是孕激素,在背部前-状回路中动态改变大脑连接. 这种荷尔蒙影响影响决策,改变大脑对延迟奖励的价值观.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 内分泌学 在内分泌学.
背景情况:
- 背部前-状回路对于认知控制和目标导向行为至关重要.
- 众所周知,卵巢激素的波动会影响大脑功能,但它们对决策的具体影响尚不清楚.
研究的目的:
- 调查雌激醇和孕如何影响决策过程中背侧前额叶皮层 (dlPFC) - 尾状通路的功能连接.
- 了解月经周期内的自然荷尔蒙变化的作用在塑造神经回路的活动.
主要方法:
- 使用延迟折扣任务来评估在不同奖励延迟的情况下的决策.
- 在月经周期的不同阶段,在dlPFC-caudate电路内测量功能连接.
- 与神经连接和行为折扣率相关的激素水平 (雌激素,孕激素).
主要成果:
- 观察到dlPFC-caudate连接的状态依赖的重新配置,与较晚的卵泡阶段相比,在中流层阶段延迟奖励的负面连接更大.
- 发现,中流阶段的孕激素水平调节了连接强度和个人折扣率之间的关系.
- 由自然荷尔蒙波动驱动的功能架构的可逆变化.
结论:
- 自然发生的荷尔蒙波动可逆地改变了背部前-上回路的功能连接.
- 这些荷尔蒙变化协调了人类决策中的依赖状态的变化,特别是在延迟奖励的估值方面.
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