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周心脂肪放射学可以预测左心室的参与,并在ARVC中提供增量预后价值
Mengqi Guo1, Jinyu Zheng1, Weihui Xie1
1Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China.
Diagnostics (Basel, Switzerland)
|December 30, 2025
概括
周心脂肪组织 (PFT) 放射学可以预测心律失常右心室肌肉病 (ARVC) 患者的左心室 (LV) 参与和主要心脏不良事件 (MACE),有助于风险分层.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 放射学 放射学是一门学科.
背景情况:
- 节律失调的右室心肌病变 (ARVC) 是一种遗传性心肌疾病.
- 左心室 (LV) 参与和主要不良心脏事件 (MACE) 是ARVC预后的关键指标.
- 需要非侵入性成像生物标志物来预测ARVC结果.
研究的目的:
- 调查心周脂肪组织 (PFT) 放射学对ARVC中LV参与的预测能力.
- 在ARVC患者中评估PFT放射和MACE之间的关联.
- 开发一种风险分层工具,将PFT放射学和右心室喷射分数 (RVEF) 结合起来.
主要方法:
- 追溯多中心研究分析了122名ARVC患者.
- 心脏磁共振 (CMR) 用于LV参与评估.
- 来自PFT的放射性评分 (RS) 被开发和验证以预测LV参与和MACE.
主要成果:
- PFT放射性评分 (RS) 有效地预测了开发和测试组中的LV参与 (AUC 0.771和0.785).
- 在5年内,高RS独立与MACE风险增加有关 (HR 3.452,p < 0.001).
- 简化风险评分整合RVEF和RS将患者分为低风险,中等风险和高风险组.
结论:
- 对于预测LV参与ARVC,PFT放射学是一个有价值的工具.
- PFT放射学与MACE显著相关,提供预后信息.
- 综合风险评分有助于对ARVC患者的风险进行分层,以改善管理.
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