在接受化疗放射治疗的头癌患者的营养干预:系统性审查和元分析
Sneha Patnaik1, Jiun-Yi Wang1,2, Fawziyyah Usman Sadiq1
1Department of Healthcare Administration, Asia University, Taichung 413305, Taiwan.
Healthcare (Basel, Switzerland)
|December 30, 2025
概括
非侵入性营养干预措施对接受化疗放射治疗的头癌患者有希望,改善体重和营养状况. 需要进一步的高质量试验来确认这些对临床实践的好处.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 基于证据的医学基于证据的医学.
背景情况:
- 头癌患者经常经历营养不良,对治疗结果和生活质量产生负面影响.
- 营养状况恶化是头癌治疗的一个重大挑战.
- 系统性审查对于评估对这一弱势群体的干预措施至关重要.
研究的目的:
- 系统地审查和元分析非侵入性营养干预措施对头癌患者的影响.
- 评估对营养状况,临床标志物和患者报告结果的影响.
- 评估营养支持策略的证据质量.
主要方法:
- 对五个数据库 (PubMed,CINAHL,ProQuest,Medline,Scopus) 的综合文献搜索,用于随机对照试验 (2019-2024年).
- 使用Joanna Briggs批判性评估工具进行数据选,提取和质量评估.
- 使用随机或固定效应模型进行的元分析,用GRADE评估证据确定性.
主要成果:
- 包括11项涉及1000名参与者的研究.
- 观察到体重 (SMD = 0.171),血清白蛋白 (SMD = 0.539),以及患者生成的主观全球评估得分 (SMD = -0.518) 的显著改善.
- 有关偏见 (盲目化,ITT偏差) 和中度至非常低的证据确定性的担忧被注意到.
结论:
- 非侵入性,患者导向的营养干预措施可能在化疗放射治疗期间为头癌患者提供临床益处.
- 这些干预措施似乎有助于维持体重和营养状况.
- 未来的研究需要强大的,强大的试验,并提供标准化的报告,以巩固临床建议.
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