增加的suPAR血水平可能表明术后败血症在开放的胸腔腹腔大动脉修复后
Dragos Socol1, Cathryn Bassett2, Bernhard Hruschka2
1Faculty of Medicine, RWTH Aachen University, Campus Aachen, 52062 Aachen, Germany.
Journal of clinical medicine
|December 30, 2025
概括
在患有败血症的患者中,溶性泌尿酶等离子激素激活体受体 (suPAR) 水平在胸腔腹腔大动脉动脉瘤 (TAAA) 修复后很早上升. 在TAAA患者中,suPAR监测显示出早期败血症检测的前景.
科学领域:
- 心血管外科心血管外科
- 传染性疾病 传染性疾病
- 生物标志物研究 生物标志物研究
背景情况:
- 开放胸腔腹腔大动脉瘤 (TAAA) 修复带有高风险的术后并发症,特别是败血症.
- 早期检测败血症对于改善TAAA修复后的患者结果至关重要.
研究的目的:
- 为了研究TAAA患者的外科手术期间可溶性尿素激酶激活酶受体 (suPAR) 血水平.
- 评估suPAR在TAAA修复后早期检测术后败血症的潜力.
主要方法:
- 对28名接受选择性开放TAAA修复的患者进行了回顾性研究.
- 在五个时间点采集的术后血液样本;用ELISA测量suPAR水平.
- 接收器运营商特征 (ROC) 分析用于评估败血症的预测性表现.
主要成果:
- 25%的患者 (7/28) 发生了败血症,诊断时间平均为手术后9.7天.
- 从手术后12小时开始,在败血症组观察到显著升高的suPAR水平 (p=0.004).
- 在手术后24小时,suPAR显示出对败血症的高预测准确性 (AUC=0.90,90%的灵敏度,在9 ng/mL切断时的86%特异性).
结论:
- 术后早期升高的suPAR水平与TAAA患者随后的败血症发展密切相关.
- 经手术的suPAR监测可以促进对败血症的及时干预.
- 这种方法可以改善高风险TAAA手术患者的结果.
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