发展中国家活着的脏捐赠者的长期结果:单中心研究
Alparslan Güneş1, Gizem Kumru1, Ebru Dumlupınar2
1Department of Nephrology, Faculty of Medicine, Ankara University, 0600 Ankara, Türkiye.
Journal of clinical medicine
|December 30, 2025
概括
活着的脏捐赠者经历了逐渐的功能下降和慢性病患病率的增加,突出了对捐赠后结构化的长期监测的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 移植手术 移植手术
- 心脏病学 心脏病学
背景情况:
- 移植可以改善末期病患者的生存率和生活质量.
- 活体捐赠者的移植是普遍存在的,特别是在发展中国家.
- 活着的脏捐赠者的长期健康结果需要彻底评估,特别是脏和心血管健康.
研究的目的:
- 评估活着的脏捐赠者的长期临床结果.
- 专注于功能,心血管事件,以及神经切除术后的代谢健康.
- 确定与脏捐赠者的不良结果相关的风险因素.
主要方法:
- 从2011年1月到2022年11月,对232个活体脏捐赠者记录进行了回顾性审查.
- 监测心血管事件,死亡率,慢性病,高血压和新发糖尿病.
- 评估功能使用估计的膜过率 (eGFR) 随着时间的推移.
主要成果:
- 随访时间中位数为6年;18.9%的捐赠者有eGFR<60mL/min/1.73m2,没有进展到末期脏疾病.
- 8.6%的患者在捐赠后出现了新发的蛋白尿症;4.3%的患者经历了严重的不良心脏事件.
- 较低的基线EGFR和捐赠后蛋白尿是降低EGFR的独立风险因素;糖尿病预测了新发性高血压.
结论:
- 活着的脏捐赠者可能会经历逐渐的功能下降和慢性脏疾病和高血压的患病率增加.
- 虽然没有捐赠者进展到末期病,但长期监测至关重要.
- 结构化的后续协议是必要的,以管理活着的脏捐赠者潜在的长期健康问题.
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