伴侣种族和辅助生殖技术的结果:一个回顾性队列研究
Shu Qin Wei1, Michael H Dahan1,2, Yu Lu1
1Origin Elle Fertility Clinic & Women's Health Centre, Montreal, QC H4A 3J3, Canada.
Journal of clinical medicine
|December 30, 2025
概括
伴侣的种族影响体外受精 (IVF) 成功率. 在英国的一项研究中,非白人伴侣与较低的临床怀孕和活产率有关.
科学领域:
- 生殖医学 生殖医学
- 在体外受精 (IVF)
- 健康差异 在健康上的差异
背景情况:
- 辅助生殖技术 (ART) 已经进步,但临床结果的差异仍然存在.
- 影响ART结果的患者因素得到了充分研究,但对伴侣种族的作用不太了解.
- 这项研究调查了伴侣种族对ART成功的影响.
研究的目的:
- 检查伴侣种族与体外受精 (IVF) 结果之间的关联.
- 为了确定伴侣的种族是否独立地影响怀孕和活产率.
- 根据合作伙伴的种族来确定ART结果的潜在差异.
主要方法:
- 在英国 (2017-2018) 进行了158,813次试管婴儿周期的回顾性队列研究.
- 暴露变量:合作伙伴的种族.
- 分析结果:生化妊娠,临床妊娠,流产和活产.
- 多变量回归模型根据患者年龄,伴侣年龄,患者种族,怀孕,不孕症诊断,治疗类型,前植入前遗传检测形,以及之前的试管婴儿周期进行调整.
主要成果:
- 白人伴侣的活产率为26.3%,非白人伴侣的活产率为23.1%.
- 非白人伴侣的临床怀孕率降低了5% (RR 0.95) 和活产率降低了6% (RR 0.94).
- 黑人和亚裔伴侣显著降低了活产率,特别是当双方都属于这些族群时,即使在调整患者种族之后.
结论:
- 伴侣的种族与试管婴儿结果独立相关,非白人伴侣的成功率较低.
- 这些发现强调了伴侣种族在生殖结果中的临床意义.
- 需要进一步的研究来了解推动这些观察到的IVF种族差异的潜在机制.
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