玉米IDF和减少多的IDF通过调节肠道微生物群和肠道屏障来缓解低剂量3-MCPD诱导的毒性
Zhiqiang Song1, Huanxiao Jiang1, Huiying Dai1
1Engineering Research Center of Plant Food Processing Technology, Ministry of Education, Qiqihar University, Qiqihar 161006, China.
Foods (Basel, Switzerland)
|December 30, 2025
概括
不溶性食纤维 (IDF) 和减少多的IDF通过改善肠道屏障功能和调节肠道微生物群来减轻3--1,2-二醇 (3-MCPD) 毒性. 这些纤维具有作为食品添加剂的潜力,可以减轻3-MCPD的不良影响.
科学领域:
- 毒理学 毒理学 毒理学
- 营养 营养 营养 营养 营养
- 微生物组研究的研究.
背景情况:
- 已知不溶性食纤维 (IDF) 中的多可降低3-chloro-1,2-propanediol (3-MCPD) 的毒性.
- 减少多的IDF对3-MCPD毒性的影响尚不清楚.
研究的目的:
- 为了比较IDF和多降低IDF (IDF-AHP) 在减轻小鼠低剂量3-MCPD毒性的疗效.
- 调查潜在的机制,包括对肠道屏障功能和微生物群的影响.
主要方法:
- 在小鼠中,用IDF或IDF-AHP给出了3-MCPD.
- 评估运动功能,结肠组织学,血清二胺氧化酶 (DAO) 水平和肠道屏障功能.
- 使用16S rRNA测序分析了肠道微生物组成.
主要成果:
- 无论是IDF还是IDF-AHP都减少了3MCPD诱导的运动障碍和结肠炎症.
- 这两种纤维都增强了肠道屏障功能,降低了血清DAO水平.
- 食纤维改变了肠道微生物的组成,特定的基因可能会调解保护作用.
结论:
- IDF和减少多的IDF可以减轻低剂量3-MCPD的毒性.
- 保护作用与改善的肠道屏障功能和改变的肠道微生物群有关.
- 这些纤维显示出作为功能性食品成分的潜力,可以减轻与3-MCPD相关的健康风险.
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