创建转录因子级联汇编集,并使用图形机器学习识别潜在的治疗点
Sonish Sivarajkumar1,2, Romy Roy3, Pratyush Tandale4
1Molecular Robotics, Kochi 682022, Kerala, India.
Genes
|December 30, 2025
概括
这项研究绘制了转录因子 (TF) 级联的地图,揭示了MYC和TP53.3等关键调节者. 这些发现为开发向癌症治疗提供了新的资源.
科学领域:
- 基因组学就是基因组学.
- 系统生物学 系统生物学
- 生物信息学是一种生物信息学.
背景情况:
- 转录因子 (TFs) 调节基因表达;它们的失调与疾病,特别是癌症有关.
- 识别TF监管网络对于了解疾病机制和开发治疗方法至关重要.
研究的目的:
- 构建一个全面的转录因子级联的综合资料.
- 为潜在的治疗向确定关键的TF和相关的生物途径.
主要方法:
- TF 相互作用来源于 STRING 数据库.
- 使用图形机器学习构建了一个知识图,然后进行路径丰富分析.
- 网络分析和PageRank算法被用来确定有影响力的TF.
主要成果:
- 创建了81488个独特的TF级联的数据集,其中最长的级联涉及62个TF.
- 确定了MYC,TP53和STAT3等具有影响力的TF.
- 丰富分析突出了与癌症相关的生物途径,并公开了知识图.
结论:
- 开发的TF级联汇编作为剖析TF相互作用的宝贵资源.
- 该资源有助于识别癌症治疗中的精准医学方法的新药标.
更多相关视频
09:58Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis
Published on: June 27, 2020
3.1K
11:32Identification of Transcription Factor Regulators using Medium-Throughput Screening of Arrayed Libraries and a Dual-Luciferase-Based Reporter
Published on: March 27, 2020
7.3K
相关概念视频
02:33Combinatorial Gene Control
9.4K
Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
The expression of more than 30,000 genes is controlled by approximately 2000-3000 transcription factors. This is possible because a single transcription factor can recognize more than one regulatory sequence. The specificity in gene...
9.4K
01:30General Transcription Factors
6.6K
Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
6.6K