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Updated: Jan 7, 2026

Long-term Silencing of Intersectin-1s in Mouse Lungs by Repeated Delivery of a Specific siRNA via Cationic Liposomes. Evaluation of Knockdown Effects by Electron Microscopy
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TSLP-IL-9轴的激活阻碍了肺纤维化中ST2缺乏的抗纤维作用

Sergei P Atamas1, Virginia Lockatell1, Zhongcheng Mei2

  • 1Department of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

International journal of molecular sciences
|December 30, 2025
PubMed
概括

遗传性ST2缺陷通过减少原蛋白,部分保护肺纤维化. 然而,它通过TSLP意外地增加了IL-9,阻碍了完全的保护. 针对TSLP可能会改善抗纤维菌疗法.

关键词:
动物模型动物模型细胞因子 细胞因子有纤维化的纤维化.肺 肺 肺 肺 肺 肺 肺 肺 肺

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