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相关概念视频

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

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Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
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Types Of Column Chromatography01:29

Types Of Column Chromatography

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The stability and compatibility of column material with samples are crucial for efficient purification in chromatographic techniques. Various operating parameters such as pH, temperature, or solvent affect the packing of the column material, thereby determining the purification efficiency. The choice of column material also plays an essential role in deciding the operating parameters and can be modified based on the proteins that need to be purified.
Gel Filtration Chromatography
When the...
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Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence01:27

Pharmaceutical Alternatives: Polymorphic Form-Related and Particle Size-Related Therapeutic Nonequivalence

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Changes in polymorphic forms can significantly influence the bioavailability of poorly soluble drugs. Although the FDA defines pharmaceutical equivalence based on having the same active ingredient, dosage form, and route of administration, it does not automatically disqualify products with different polymorphic forms. This means two products with different polymorphs can still be deemed pharmaceutically equivalent. However, polymorphic differences can affect properties like wettability,...
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Colloids and Suspensions01:17

Colloids and Suspensions

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Children at play often make suspensions such as mixtures of mud and water, flour and water, or a suspension of solid pigments in water known as tempera paint. These suspensions are heterogeneous mixtures composed of relatively large particles visible to the naked eye or seen with a magnifying glass. They are cloudy, and the suspended particles settle out after mixing. The suspended particles in a suspension settle out after some time of mixing. The separation of particles from a suspension is...
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Positive Regulator Molecules02:39

Positive Regulator Molecules

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Mitotic cell division results in daughter cells that exactly resemble the parent cell. However, errors in the DNA replication or distribution of genetic material may lead to genetic mutations that may be passed down to every new cell formed from the resulting abnormal cell. Propagation of such mutant cells is restricted through checkpoint mechanisms present at different stages of the cell cycle. These checkpoints involve regulator molecules that either promote or demote cell cycle events.
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Secondary Active Transport01:32

Secondary Active Transport

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One example of how cells use the energy contained in electrochemical gradients is demonstrated by glucose transport into cells. The ion vital to this process is sodium (Na+), which is typically present in higher concentrations extracellularly than in the cytosol. Such a concentration difference is due, in part, to the action of an enzyme "pump" embedded in the cellular membrane that actively expels Na+ from a cell. Importantly, as this pump contributes to the high concentration of...
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study
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Transport Properties of Ibuprofen Encapsulated in Cyclodextrin Nanosponge Hydrogels: A Proton HR-MAS NMR Spectroscopy Study

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专题号: 循环德克斯:特性和应用,第二版.

Miguel A Esteso1,2, Carmen M Romero3

  • 1Facultad de Ciencias de la Salud, Universidad Católica de Ávila, Calle los Canteros s/n, 05005 Ávila, Spain.

International journal of molecular sciences
|December 30, 2025
PubMed
概括

循环德克斯特林 (CDs) 是由粉衍生的循环寡糖. 这些分子具有独特的超分子结构,在各种科学领域具有多样化的应用.

科学领域:

  • 生物化学 生化学
  • 超分子化学 超分子化学
  • 碳水化合物化学 碳水化合物化学

背景情况:

  • 环极素 (CDs) 是由酶性粉降解产生的循环寡糖.
  • 它们具有独特的状或圆状的超分子结构.
  • 这种结构使它们能够与各种客分子形成包含综合体.

研究的目的:

  • 为了探索循环德克斯特林的基本性质.
  • 在不同科学领域研究循环素的多样化应用.
  • 突出环极在超分子化学和药物输送中的重要性.

主要方法:

  • 粉的酶降解以产生环氧素.
  • 使用光谱和晶体学技术对循环德克斯特林结构的表征.
  • 通过结合性研究和分子建模,研究包容复合体形成.

主要成果:

  • 证实了环极的特征性高分子结构.
  • 展示了环极素能够封装广泛的客分子的能力.
  • 证据表明,在循环德克斯特林复合体内,客分子的可溶性和稳定性得到了增强.

结论:

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  • 环极是具有独特超分子结构的多功能分子.
  • 它们形成包容性复合物的能力使它们在药物输送,食品科学和环境应用中具有价值.
  • 对循环德克斯特林衍生物的进一步研究有望为新型应用提供希望.