从自身免疫性肌炎到中枢疼痛:假设纤维肌痛和初级斯乔格伦病的共享病原体,并确定必要的查策略
Marta Magdalena Jaskólska1,2, Iga Kościńska-Shukla1,2, Kinga Grochowalska1,2
1Department of Rheumatology, Clinical Immunology, Geriatrics and Internal Medicine, Medical University of Gdańsk, 80-214 Gdańsk, Poland.
International journal of molecular sciences
|December 30, 2025
概括
纤维肌痛 (FM) 经常与初级Sjögren一起发生.
科学领域:
- 类风湿病学 类风湿病学
- 神经学 神经学
- 免疫学 免疫学 免疫学
背景情况:
- 主要Sjögren病 (pSjD) 呈现出病态症状,但也存在严重的腺外表现.
- 多神经病,肌肉病和纤维肌痛 (FM) 是影响患者生活质量的重大问题.
- 在pSjD中FM的高患病率使诊断和治疗复杂化.
研究的目的:
- 为了确定pSjD和FM的同时出现的频率.
- 为了确定有效的选工具和生物标志物,以此重叠.
- 探索潜在的潜在机制和治疗影响.
主要方法:
- 97名pSjD患者填写了问卷:纤维肌痛调查问卷,SF-36,以及EULAR斯乔格伦综合征患者报告指数 (ESSPRI).
- 分析了中枢神经系统 (CNS) 异常的实验室结果,电神经图 (ENG),电肌图 (EMG) 和MRI.
- 使用EULAR Sjögren综合征疾病活动指数 (ESSDAI) 评估疾病活动.
主要成果:
- 45%的pSjD患者符合FM的诊断标准.
- 在MRI上,FM诊断与中枢神经系统参与有显著的相关性.
- ESSPRI总和疼痛得分与FM有正相关,而SF-36得分显示出负相关性.
结论:
- 纤维肌痛是Sjögren原发性疾病中常见的并发症,需要不同的治疗策略.
- 欧拉Sjögren综合征患者报告指数 (ESSPRI) 可以帮助对PSjD患者进行初始FM查.
- 中枢敏感化和微质极化是需要进一步分子调查的潜在病因因素.
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