在血栓形成和血液静止中的纤维素单体:临床生物标志物和超越
Konstantin Guria1, Ivan Melnikov1,2, Valentina Shtelmakh1
1National Medical Research Centre of Cardiology Named After Academician E.I. Chazov, Ministry of Health of the Russian Federation, 15A Akademika Chazova Street, 121552 Moscow, Russia.
International journal of molecular sciences
|December 30, 2025
概括
纤维素单体 (FM) 是血液凝固的关键调节剂,也是凝固风险的生物标志物. 本综述探讨了其机制和临床用途,用于评估诸如中风和心脏病发作等疾病.
科学领域:
- 血液学 血液学 血液学
- 生物化学 生物化学
- 临床医学 临床医学
背景情况:
- 纤维素单体 (FM) 是血液凝固的关键中间体.
- 它既是血液静止的调节剂,又是前血栓状况的生物标志物.
- 从临床上看,FM通常是间接地作为可溶性纤维素单体复合物 (SFMC) 测量.
研究的目的:
- 审查FM在血液静止调节中的分子机制.
- 评估支持FM作为血栓状况生物标志物的临床证据.
- 讨论FM临床应用的挑战和未来方向.
主要方法:
- 关于FM在血液静止中的作用的综合文献综述.
- 分析涉及FM,血小板和凝固因子的分子相互作用.
- 对FM作为各种血栓性疾病的生物标志物的临床研究的评估.
主要成果:
- FM在调节血栓生成和纤维素分解方面发挥着复杂的作用.
- FM与血小板受体 (整体蛋白αIIbβ3,GPVI) 和GPIb-vWF相互作用相互作用.
- 临床数据支持FM在包括VTE,中风,心脏病发作和COVID-19凝血病等疾病的风险分层中的实用性.
结论:
- FM复杂的分子功能对于血液静止至关重要.
- 作为评估血栓形成风险的生物标志物,FM显示出显著的前景.
- 为了更广泛的临床采用,需要对测试的标准化和通用截止值进行标准化.
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