在雌激素介导的调节Fam3d在小鼠子宫在雌激素周期期间
Hyukjung Kim1, Byeongseok Kim1, Joohee Kim1
1Department of Stem Cell and Regenerative Biotechnology, Konkuk University, Seoul 05029, Republic of Korea.
International journal of molecular sciences
|December 30, 2025
概括
雌激素通过雌激素受体α (ERα) 调节小鼠子宫中的Fam3d基因表达,暗示FAM3D.
科学领域:
- 生殖生物学 生殖生物学
- 分子内分泌学分子内分泌学
- 子宫生理学子宫生理学
背景情况:
- 子宫经历了生殖至关重要的周期性变化,受雌激素和孕激素等激素的影响.
- 在子宫中,Fam3基因家族的功能在很大程度上是未知的.
- 了解子宫基因调节对于生殖健康至关重要.
研究的目的:
- 为了研究Fam3基因家族在雌激周期期间在小鼠子宫中的表达模式.
- 确定雌激素和雌激素受体α (ERα) 在调节Fam3d表达中的作用.
- 为了阐明FAM3D蛋白在子宫组织中的细胞局部.
主要方法:
- RNA测序 (RNA-seq) 用于分析Fam3基因表达在整个雌性周期中的情况.
- 在卵巢切除的小鼠中使用雌激醇和ERα抗剂进行激素操纵.
- 免疫光显微镜以确定FAM3D蛋白位址.
主要成果:
- 在前期和前期期间,Fam3b,Fam3c和Fam3d的表达增加.
- Fam3d表达是动态调节的,在前期和前期达到峰值.
- 雌激素的使用以时间依赖的方式诱导Fam3d的表达,并被ERα抗剂阻断.
- FAM3D蛋白在子宫上皮细胞的细胞质中局部化.
结论:
- 通过ERα信号传递,雌激素控制了小鼠子宫中的Fam3d基因表达.
- FAM3D与子宫上皮细胞功能有关.
- 这项研究为Fam3d在生殖过程中的作用提供了基础知识.
相关概念视频
01:22Hormonal Regulation of the Menstrual Cycle
1.4K
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH...
1.4K
01:30Hormonal Control of the Ovarian Cycle
6.3K
The ovarian cycle is meticulously regulated by the hypothalamic-pituitary-gonadal axis. This cycle orchestrates the release of a mature oocyte, essential for reproduction.
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
Before puberty, the hypothalamus releases GnRH in a low frequency, low amplitude pulsatile manner. This along with the immature hypothalamic-pituitary-gonadal axis activity, results in low estrogen levels and the absence of a fully functional ovarian cycle. At puberty, GnRH secretion increases in both frequency and...
6.3K
01:27Feedback Regulation of Calcium Concentration
3.9K
Calcium is an essential signaling molecule required for various cellular functions. Calcium pumps and ion channels on cell and organellar membranes, such as those on the endoplasmic reticulum (ER), regulate calcium concentrations inside the cell. They remain closed, keeping the cytosolic calcium levels low at a resting state.
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
3.9K