探索在电中暴露于和的工人中肝功能障碍的分子机制
Mona Abdallah Ramadan1, Marwa Abdelgwad2, Reem T Atawia3,4
1Occupational and Environmental Medicine Department, Faculty of Medicine, Cairo University, Al Giza 12613, Egypt.
International journal of molecular sciences
|December 30, 2025
概括
职业接触 (Ni) 和 (Cr) 会损害肝脏. 这项研究发现,电工人暴露于Ni和Cr会导致肝功能受损,氧化应激,并通过Nrf2通路引起炎症.
科学领域:
- 毒理学 毒理学 毒理学
- 职业健康 职业健康 职业健康
- 分子生物学分子生物学
背景情况:
- (Ni) 和 (Cr) 的暴露在职业环境中很常见.
- 肝脏是Ni和Cr毒性的主要目标器官.
- 了解Ni和Cr诱导的肝损伤的分子机制至关重要.
研究的目的:
- 评估暴露于Ni和Cr的工人的肝功能.
- 研究这些工人肝损伤的分子机制.
- 为了评估氧化应激和炎症标志物.
主要方法:
- 一个金工厂86名男性员工的横截面研究.
- 测量了血清Ni,Cr,肝功能测试,氧化应激标志物 (SOD,GPx,MDA) 和炎症指标 (NF-κB).
- 评估了Keap-1,Nrf2,Ho-1和miR-223的基因表达.
主要成果:
- 与对照组相比,电工人显示血清Cr,Ni,肝转氨酶,总胆红素和NF-κB的显著升高.
- 在电中,血清白蛋白水平较低.
- 氧化应激明显减少了SOD和GPx,增加了MDA;Keap-1上调,而Nrf2/Ho-1和miR-223则下调.
结论:
- 职业Ni和Cr暴露与肝功能障碍有关.
- 这种损害是由抗氧化剂Nrf2通路的降低调节,氧化应激增加和炎症介导的.
- 这些发现突显了Ni和Cr对暴露工人的肝脏健康的有害影响.
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