植物成分抑制线粒体氧化酸化以预防HER2阳性乳腺癌,并识别潜在活性化合物
Yi Zhao1, Wenxiu Hu1, Xinnan Wang1
1Research Center for Differentiation and Development of Basic Theory of Traditional Chinese Medicine, Jiangxi University of Chinese Medicine, Nanchang 330004, China.
International journal of molecular sciences
|December 30, 2025
概括
草药化合物SLC通过向线粒体功能和HER2信号通路,有效地抑制HER2阳性乳腺癌的进展. 这种自然治疗减少了瘤的生长,并在临床前模型中诱导了亡.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 生物化学 生物化学
背景情况:
- HER2阳性乳腺癌是侵略性的,治疗选择很少.
- 传统中医药草药显示潜在的抗瘤作用.
- SLC是一种新的草药成分,具有潜在的治疗益处.
研究的目的:
- 研究SLC对HER2阳性乳腺癌的抑制作用.
- 阐明SLC作用的基本机制.
- 在临床前模型中评估SLC的疗效.
主要方法:
- 使用UPLC-Q/TOF-MS进行化合物识别.
- 在体外测试细胞增殖,迁移和线粒体功能.
- 西部斑点分析用于信号通路评估.
- 在体内异种移植模型用于瘤生长评估.
- 分子对接用于活性成分识别.
主要成果:
- 通过减少葡萄糖吸收和ATP生产,SLC抑制了细胞增殖,迁移和线粒体功能.
- SLC降低了p-HER2/HER2,p-AKT/AKT和p-ERK/ERK的调节,抑制了HER2通路.
- SLC影响了PDK1/PDHA1和SIRT1/PGC-1α/NRF1/TFAM信号传递,影响了氧化酸化.
- 在体内,SLC抑制了瘤的生长;单甲基石酸盐被确定为关键成分.
结论:
- SLC显示出对HER2阳性乳腺癌的显著抑制作用.
- SLC通过调节线粒体的氧化酸化和HER2信号通路而起作用.
- 在HER2阳性乳腺癌中,SLC是一个有前途的治疗策略.
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