分子机制驱动准确医学在外科护理:整合炎症,新陈代谢和神经免疫调节以实现个性化的结果
Ann-Kathrin Wenner1, Lukas Andereggen2,3, Markus M Luedi1,4
1Department of Anaesthesiology, Rescue- and Pain Medicine, Cantonal Hospital of St. Gallen, 9007 St. Gallen, Switzerland.
精密外科手术周围医学使用炎症,新陈代谢和神经免疫调节来定制患者治疗. 本文重点介绍了用于预测外科手术风险和改善康复结果的多种omics和分析.
科学领域:
- 在外科手术期间的医学.
- 翻译科学 翻译科学
- 系统生物学 系统生物学
背景情况:
- 精确的外科外科医学集成了炎症,新陈代谢和神经免疫调节.
- 预测患者的风险和个性化治疗是外科手术的关键挑战.
- 最近的进展侧重于多组学和临床分析.
研究的目的:
- 审查精准外科手术周边医学的里程碑式概念和最近的研究 (2017-2025年).
- 概述多组学和临床分析如何将生物数据转化为可操作的治疗途径.
- 确定改善患者治疗结果的关键机会.
主要方法:
- 标志性研究和最新研究 (2017-2025) 的文献综述.
- 分析多主题数据和临床分析以确定途径.
- 专注于炎症,新陈代谢和神经免疫调节机制.
主要成果:
- 关键的机会包括细胞因子引导的风险分层,代谢条件和自主神经调节.
- 准胆固醇抗炎反射是一种有希望的策略.
- 将生物见解转化为临床实践是可行的.
结论:
- 强大的表型和可互操作的数据管道对于实施至关重要.
- 未来的试验应侧重于功能恢复和认知结果.
- 精确的外科外科医学具有优化外科护理的巨大潜力.
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