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涉及HCV感染和人类HCC的表观遗传机制

Ximenya Glauce da Cunha Freire Lopes¹, Roque Ribeiro da Silva Júnior², Fernando Liberalino Fernandes³

¹Postgraduate Program in Parasitic Biology (PPGBP), Federal University of Rio Grande do Norte (UFRN), Natal 59078-900, Brazil.

International journal of molecular sciences

|December 30, 2025

概括

像miRNA,lncRNA和circRNA这样的非编码RNA (ncRNA) 在C型肝炎病毒 (HCV) 感染和肝癌 (HCC) 中至关重要. 这些分子具有双重作用,影响病毒复制和瘤抑制,提供潜在的诊断和治疗点.

科学领域:

表观遗传学在表观遗传学中,表观遗传学是指表观遗传学.
肝病学肝病学是一种肝病学.
病毒学病毒学
在瘤学瘤学.

背景情况:

型肝炎病毒 (HCV) 感染是一个重要的全球健康问题,经常导致慢性肝病和肝细胞癌 (HCC).
非编码RNAs (ncRNAs) 的表观遗传调节因其在病毒病原和癌症发展中的关键作用而越来越受认可.
了解HCV感染中ncRNAs的复杂相互作用对于开发有效的治疗方法至关重要.

研究的目的:

提供微RNA (miRNA),长非编码RNA (lncRNA) 和圆形RNA (circRNA) 在HCV诱导的肝损伤中的功能综合概述.
突出这些ncRNA在病毒复制和瘤抑制中的双重作用.
讨论ncRNAs作为HCV相关HCC的诊断生物标志物和治疗点的潜力.

主要方法:

文献综述综合了关于HCV感染和HCC中ncRNA的当前研究.
分析miRNAs,lncRNAs和circRNAs在病毒病原发生中的功能作用.
检查ncRNA相互作用网络,包括分子海绵机制,以及它们对肝脏平衡的影响.

主要成果:

ncRNAs在HCV感染中表现出双重作用,其中一些促进病毒复制,而另一些则作为瘤抑制剂.
失调的ncRNAs,包括作为miRNA海绵的lncRNAs和circRNAs,破坏肝脏平衡,促进炎症和瘤发生.
特定的ncRNA特征与HCV感染和HCC发展有关.

结论:

ncRNAs是HCV病原和肝癌发生的关键表观遗传调节者.
ncRNA相互作用网络对于维持肝脏健康至关重要,并且在HCV感染期间会被破坏.
ncRNAs代表了有前途的诊断生物标志物和治疗点,用于管理HCV相关的肝病和HCC.

关键词:

表观基因组学是指表观基因组学.肝炎病毒 (hepacivirus) 是一种病毒.这是一个RNARNARNARNARNA.

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