在慢性非传染性疾病中运动诱导的分子适应-叙述审查
Héctor Fuentes-Barría1,2, Raúl Aguilera-Eguía3, Miguel Alarcón-Rivera4
1Vicerrectoría de Investigación e Innovación, Universidad Arturo Prat, Iquique 1110939, Chile.
International journal of molecular sciences
|December 30, 2025
概括
定期的体育炼通过触发分子和细胞适应提供了显著的健康益处. 这些适应改善了代谢健康,并有助于预防2型糖尿病和心血管疾病等慢性疾病.
科学领域:
- 分子生物学分子生物学
- 运动生理学 运动生理学
- 代谢健康 代谢健康
背景情况:
- 运动是治疗慢性非传染性疾病 (NCD) 的关键非药物治疗方法.
- 运动的好处源于分子和细胞的适应,而不仅仅是生理上的变化.
- 了解这些机制对于个性化医学至关重要.
研究的目的:
- 审查运动改善代谢健康的机制.
- 为了突出细胞内信号传递,表观遗传调节和肌沟通.
- 为有针对性的,以练习为基础的干预提供基础.
主要方法:
- 文献综述综合当前知识.
- 强调细胞内信号通路 (例如AMPK,PGC-1α,mTOR).
- 专注于由myokine驱动的器官间通信和表观遗传调节.
主要成果:
- 运动激活关键信号通路,增强线粒体功能,减少炎症.
- 肌肉收缩释放神经激素,调节新陈代谢,神经可塑性和炎症.
- 表观遗传修饰有助于长期的代谢重编程.
结论:
- 运动充当全身刺激,恢复新陈代谢平衡.
- 分子适应对抗NCD病理生理学.
- 这些知识有助于开发个性化的运动干预措施.
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