对替代的素生产策略进行系统审查
Masoumeh Zeinali1, Mohammad Sabzehzari2, Didier Ménard3,4,5,6
1Division of Biotechnology, Department of Agronomy and Plant Breeding, Faculty of Agricultural, University of Mohaghegh Ardabili, Ardabil 5611911367, Iran.
International journal of molecular sciences
|December 30, 2025
概括
来自Artemisia annua的艺术素 (ART) 的低产量需要新的生产方法. 本综述探讨了增强植物含量,体外培养,植物表达和半合成途径,以实现可持续的ART供应.
科学领域:
- 药物鉴定学和生物技术
- 药物发现和开发 药物发现和开发
- 代谢工程是代谢工程.
背景情况:
- 素 (ART) 产量受限于其天然来源的低产和不一致的产量,Artemisia annua.
- 除了疟疾之外,扩大ART的治疗应用需要改进和可持续的生产战略.
- 当前的生产方法在满足全球需求和确保持续供应方面面临着挑战.
研究的目的:
- 系统地审查和综合关于艺术素 (ART) 替代生产平台的证据.
- 确定和评估新兴的战略,以提高ART产量和可访问性.
- 为可持续和可扩展的ART生产提供路线图.
主要方法:
- 在主要科学数据库 (PubMed,Scopus,Web of Science,Google Scholar) 的系统文献搜索,查找2020-2025年间发表的研究.
- 包括详细介绍ART生产策略的初级研究文章.
- 根据生产主题分类的数据的叙事综合.
主要成果:
- 确定了ART生产的四个关键前沿:增强AI. 年度含量,利用体外平台 (和细胞培养),其他植物中的异质表达,以及通过微生物发酵的半合成途径.
- 试管体内方法提供控制,但面临可扩展性问题.
- 人工智能驱动的预测建模正在成为优化源发现和生产流程的工具.
结论:
- 增强自然生产,先进的生物技术平台和半合成方法的结合为可持续的ART生产提供了一个有希望的路线图.
- 解决体外培养中的扩大瓶问题和利用人工智能对于未来的进步至关重要.
- 整合这些不同的策略可以确保为全球卫生需求提供强大可靠的ART供应.
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