青少年双杆菌加强肠道屏障 在旅行后功能性便秘中
Huidie Zhao1,2, Hongli Wang1, Xinyuan Zhao1,2
1Center of Translational Medicine Research, Naval Medical University, Shanghai 200433, China.
International journal of molecular sciences
|December 30, 2025
概括
这项研究发现,Bifidobacterium adolescentis是一种益生菌,通过改善肠道健康和恢复微生物平衡,有效治疗小鼠功能性便秘. 它为改善肠道健康提供了潜在的治疗策略.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 益生菌 益生菌 益生菌
背景情况:
- 长时间的航行会导致功能性便秘,影响工作效率.
- 双杆菌在治疗功能性便秘方面表现有前途,但影响是菌株特异性的.
- 需要对旅行前便样本进行研究,以确定有效的Bifidobacteria菌株.
研究的目的:
- 研究肠道微生物群在中风后便秘中的作用.
- 确定针对性便秘治疗的微生物生物标志物.
- 评估Bifidobacterium adolescentis的治疗潜力.
主要方法:
- 基因组分析以确定B. adolescentis. 的存在.
- 在小鼠模型中,便悬浮和B. adolescentis口服.
- 评估便体积,肠道运动性,杯细胞和微生物组成.
主要成果:
- 青少年治疗改善了便体积,肠道运动性和杯状细胞.
- 恢复了微生物平衡,减少了大肠杆菌和克莱布西拉菌.
- 正常化氨酸/胆酸代谢和特定的信号通路.
结论:
- B. adolescentis在改善功能性便秘方面表现出有效性.
- 确定了B. adolescentis作为潜在的益生菌对肠道健康.
- 提供了关于便秘和益生菌治疗背后的微生物机制的见解.
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