棕酸但不是油性酸诱导人体内皮细胞从不同血管床的亲炎性功能障碍在体外
Daria Shishkova1, Victoria Markova1, Yulia Yurieva1
1Department of Experimental Medicine, Research Institute for Complex Issues of Cardiovascular Diseases, 6 Barbarash Boulevard, 650002 Kemerovo, Russia.
International journal of molecular sciences
|December 30, 2025
概括
棕酸 (PA) 导致人类大动脉和沙静脉内皮细胞 (ECs) 中显著的细胞损伤和炎症. 油酸 (OA) 的作用较轻,而内胸动脉EC对这两种脂肪酸的抵抗力最强.
科学领域:
- 心血管生物学 心血管生物学
- 细胞生物学 细胞生物学
- 营养科学 营养科学
背景情况:
- 棕酸 (PA) 和油酸 (OA) 是常见的饮食脂肪酸,具有不同的特性.
- 内皮细胞 (ECs) 形成血管的内壁,在血管健康中起着至关重要的作用.
- 来自各种血管床的EC对PA和OA的差异反应尚不清楚.
研究的目的:
- 研究PA和OA在不同血管来源的人类EC上显著的细胞毒性和促炎作用.
- 为了比较主动脉,静脉,内胸动脉和微血管ECs对这些脂肪酸的敏感性.
主要方法:
- 人类主要大动脉 (HAVEC),静脉 (HSaVEC),内胸动脉 (HITAEC) 和微血管 (HMVEC) 的脑电动脉被用与蛋白结合的PA或OA治疗了24小时.
- 评估了细胞毒性,并分析了细胞粘附分子和促炎细胞因子的基因表达.
- 测量了关键炎症调解剂的释放,例如介质素-6和-8的释放.
主要成果:
- 在EC中,PA诱导了显著的细胞毒性,并增加了粘附分子 (VCAM1,ICAM1,SELE,SELP) 和促炎细胞因子的表达.
- HAVEC和HSaVEC对PA最敏感,表现出白内素-6和-8释放的增加.
- 在HAVEC和HMVEC中,OA在没有广泛的EC激活的情况下表现出轻度至中度的细胞毒性,而HITAEC则对这两种脂肪酸都表现出耐药性.
结论:
- 在不同血管床的EC对棕酸的反应中存在显著的异质性.
- 与油酸相比,棕酸对内皮功能障碍的风险更大,特别是在某些血管EC中.
- 了解这些差异性反应对于评估食脂肪酸对血管的影响至关重要.
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