肠-大脑轴和胆酸信号传递:将微生物代谢与大脑功能和代谢调节联系起来
Bojan Stanimirov1, Maja Đanić2, Nebojša Pavlović3
1Department of Biochemistry, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia.
International journal of molecular sciences
|December 30, 2025
概括
由肠道微生物修饰的胆汁酸在肠-大脑轴中起着关键的信息传递作用. 这些信号分子影响大脑功能,为代谢和神经退行性疾病提供治疗潜力.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 代谢过程中的代谢.
背景情况:
- 肠-大脑轴涉及肠道微生物群和中枢神经系统 (CNS) 之间的双向通信.
- 胆酸是肠道微生物群产生的关键代谢物,显著影响中枢神经系统功能.
- 这些代谢物调节代谢和神经内分泌通路,影响神经元活动和能量平衡.
研究的目的:
- 审查胆汁酸调解肠道微生物群-中枢神经系统通信的机制.
- 探索胆汁酸在调节代谢和神经内分泌功能中的作用.
- 突出针对代谢和神经退行性疾病中的胆酸信号的治疗潜力.
主要方法:
- 综合微生物学,代谢和神经内分泌研究的文献综述.
- 通过肠道微生物群对胆汁酸修饰的分析.
- 检查胆酸与中枢神经系统受体 (如FXR和TGR5.5) 的相互作用.
主要成果:
- 微生物修饰的胆酸作为信号分子,影响神经元活动,食欲,葡萄糖代谢和能量平衡.
- 胆酸通过内分泌和免疫路径直接和间接地影响中枢神经系统.
- 胆汁酸激活受体 (FXR,TGR5) 是将肠道微生物活动与大脑功能联系起来的关键机制.
结论:
- 胆酸是肠-大脑轴中的关键信使,将微生物代谢与中枢神经系统功能连接起来.
- 了解这些相互作用为新的治疗策略开辟了道路.
- 向胆酸通路可能为代谢和神经退行性疾病提供新的治疗方法.
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