三重追踪器哨兵节点映射:最大限度地检测,最大限度地减少剖析
Daniel Alin Cristian1,2, Bogdan Popescu1,3, Cristian Valentin Toma1,4
1Faculty of General Medicine, Carol Davila University, 050474 Bucharest, Romania.
Life (Basel, Switzerland)
|December 30, 2025
概括
技术-99m和绿是乳腺癌中哨兵淋巴结活检的有效标记物,表现优于甲蓝. 三重追踪方法提高了检测,并可以减少删除的节点数量.
科学领域:
- 在瘤学瘤学.
- 手术瘤学手术瘤学
- 核医学是一种核医学.
背景情况:
- 哨兵淋巴结 (SLN) 活检对于乳腺癌的分期至关重要.
- 通常使用的标记物包括技术-99m (99mTc),绿 (ICG) 和甲蓝 (MB).
- 关于在常规临床实践中这些标记物的比较性能的数据有限.
研究的目的:
- 审核99mTc,ICG和MB在乳腺癌中SLN活检的三重追踪方法中的性能.
- 为了评估哨兵淋巴结检测率,检索的节点数量和追踪器一致性.
- 评估子组的表现,包括接受乳房切除术或后新辅助治疗的患者.
主要方法:
- 一个单一中心对111个连续的SLN程序进行了追溯审计.
- 使用了结合99mTc,ICG和MB的三重追踪方法.
- 评估检测率,节点收益率,追踪器一致性和特定患者子组.
主要成果:
- 99mTc的检测率为96.4%,ICG为93.7%,MB的检测率为78.4%.
- 99mTc和ICG显著超过了MB的表现 (p < 0.001).
- 三重追踪器工作流改善了检测几率 (99mTc的AUC为0.98,ICG为0.82).
结论:
- 技术仍然是SLN活检的主要标记物.
- ICG是一个有价值的辅助,增强可视化和检测效率.
- MB提供了冗余性;三重追踪器映射提供了最佳的节点识别,并可能减少完全一致的切除.
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