个性化补充与减少炎症生物标志物有关:一项为期12周的观察性研究
Eliza Roeth1, Madeline Morris1, Asher P Reynolds1
1Department of Cell Biology and Physiology, Brigham Young University, Provo, UT 84602, USA.
一个为期12周的个性化补充计划显著降低了关键的炎症标志物,如C-反应蛋白 (CRP) 和同氨酸. 这种精确的健康方法对管理系统性炎症和免疫失调有希望.
科学领域:
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
- 内分泌学 在内分泌学.
背景情况:
- 慢性低度炎症与心血管疾病,代谢功能障碍,自身免疫性疾病和认知能力下降有关.
- 血液生物标志物,如C反应蛋白 (CRP),费里丁,同型半氨酸,白细胞 (WBC) 计数和抗甲状腺过氧化酶 (anti-TPO) 抗体,对于监测全身炎症至关重要.
研究的目的:
- 评估12周个性化,生物标志物指导的补充计划对炎症和免疫标志物的影响.
- 为了在不同年龄和性别的群体中评估这些影响.
主要方法:
- 48名参与者按性别和年龄 (40-69岁) 分层,在基线和12周进行血液检查.
- 个性化协议涉及微量营养素 (维生素D,欧米茄-3,B族维生素,,),激素支持和基于个体生物标志物配置文件的.
- 主要结局测量了CRP,费里丁,同型半氨酸,白细胞计数和抗TPO抗体的百分比变化.
主要成果:
- 在所有组中,CRP降低了33-46%,同型半氨酸降低了29-37%,白细胞计数降低了22-28%.
- 在男性中 (高达48%),特别是老年人群中,费里丁的减少是显著的.
- 女性的抗TPO抗体水平下降更大 (高达22%).
结论:
- 由生物标志物指导的个性化补充方案有效地减少了炎症和免疫失调的关键标志物.
- 研究结果表明,基于精确度的健康优化具有潜在的有效性.
- 需要进行更大的随机对照试验来证实这些效应.
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