在美国妇女中,PFAS暴露和HPG轴激素之间的关联
Yu-Wei Fang1,2, Ching-Way Chen3, Hsuan-Cheng Lin4
1Division of Nephrology, Department of Internal Medicine, Shin-Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.
Life (Basel, Switzerland)
|December 30, 2025
概括
血清中和多醇基物质 (PFAS) 暴露与美国女性的生殖激素变化有关. 较高的PFAS水平与卵泡刺激激素 (FSH) 的增加以及抗米勒尔激素 (AMH),雌激素和孕激素的降低有关.
科学领域:
- 环境健康 环境健康
- 内分泌学 在内分泌学.
- 生殖科学 生殖科学
背景情况:
- 和多基基物质 (PFAS) 是持久的环境污染物.
- 越来越多的证据表明,潜在的不良健康影响,包括内分泌干扰.
- 妇女的生殖健康是环境暴露的关键关注领域.
研究的目的:
- 调查血清PFAS度与美国女性关键生殖激素之间的关联.
- 检查与卵泡刺激激素 (FSH),抗米勒尔激素 (AMH),雌激素和孕激素的关系.
- 评估女性生殖系统中与PFAS暴露相关的潜在内分泌干扰.
主要方法:
- 采用2017-2018年国家健康和营养检查调查 (NHANES) 数据进行的横截面研究.
- 包括612名18岁及以上的美国女性,他们有PFAS和性激素测量.
- 使用质谱学分析了四种主要的PFAS (n-PFOA,PFOS,PFNA,PFHxS) 和生殖激素的血清度.
主要成果:
- 较高的血清PFAS度与显著增加的FSH水平有关.
- 增加的PFAS水平与AMH,雌激醇和孕的降低相关.
- 一个PFAS暴露指数显示了荷尔蒙变化的一致模式,特别是在绝经前妇女中.
结论:
- 暴露于PFAS与女性广泛的内分泌干扰有关,影响性腺激素和性类固醇.
- 研究结果表明,暴露于PFAS与激素特征相关,这表明卵巢储备减少.
- 迫切需要进一步的纵向研究和监管行动,以减少PFAS暴露并保护生殖健康.
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