相关实验视频

Updated: Jan 7, 2026

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

双A在促进食道癌的分子机制基于网络毒理学和分子对接

Ming Hou¹, Hanbing Jia², Chongyang Liu¹

¹Department of Thoracic Surgery, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.

|December 30, 2025

概括

双A (BPA) 是一种内分泌干扰物,可能通过影响HSP90AA1/HSP90AB1通路来促进食道癌 (ESCA). 这项研究揭示了ESCA预防和治疗的潜在分子标.

科学领域:

环境毒理学环境毒理学
分子瘤学分子瘤学
生物信息学是一种生物信息学.

背景情况:

双甲 (BPA) 是一种内分泌干扰化学物质,具有与各种癌症相关的雌激素活性.
通过BPA促进食道癌 (ESCA) 进展的特定分子机制尚不清楚.

研究的目的:

阐明BPA可能促进ESCA进展的分子途径.
根据BPA的行动,确定ESCA的潜在治疗目标.

主要方法:

网络毒理学方法集成多个公共数据库来识别BPA目标和ESCA相关基因.
蛋白质与蛋白质相互作用 (PPI) 网络分析,丰富分析和分子对接以确定关键基因和相互作用.
使用癌症基因图集 (TCGA) 进行基因表达,生存分析和cBioPortal进行突变分析的验证.

主要成果:

确定了BPA和ESCA之间95个重叠的目标,突出显示HSP90AA1和HSP90AB1作为中央枢纽基因.
BPA对HSP90AA1和HSP90AB1.1表现出强烈的结合亲和力.
在ESCA组织中,HSP90AA1和HSP90AB1的高表达与生存率较差相关,HSP90AB1的变异频率很高.

结论:

乙A可能会通过通过HSP90AA1/HSP90AB1.1介导的瘤和免疫炎症途径推动ESCA的进展.
这些发现提高了对环境致癌性的理解,并建议HSP90AA1/HSP90AB1作为ESCA干预的潜在目标.

关键词:

在HSP90AA1AA1中使用.这就是HSP90AB1A.在TCGA中,TCGA就是TCGA.双 A 是一种双 A.内分泌干扰者是什么?内分泌干扰者这是食道癌,食道癌.分子对接的分子对接.突变分析的分析方法网络毒理学网络毒理学

更多相关视频

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Assessment of the Effects of Endocrine Disrupting Compounds on the Development of Vertebrate Neural Network Function Using Multi-electrode Arrays

Published on: April 26, 2018

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Modeling Oral-Esophageal Squamous Cell Carcinoma in 3D Organoids

Published on: December 23, 2022

相关概念视频

Barrett Esophagus-I: Introduction

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...

Mutagenicity and Carcinogenicity

Mutagenicity and Carcinogenicity

Mutagenicity and carcinogenicity refer to the ability of drugs to cause genetic defects and induce cancer, respectively. The International Agency for Research on Cancer (IARC) classifies agents into four groups based on their carcinogenic potential. Group 1 agents are known human carcinogens; group 2A agents are probably carcinogenic to humans; group 3 agents lack data to support their role in carcinogenesis; and group 4 includes agents for which data support that they are not likely to be...

Toxic Reactions: Overview

Toxic Reactions: Overview

When toxic substances penetrate the human body, they disseminate to various tissues, undergoing metabolic changes. This process yields reactive metabolites that may covalently bind with specific target molecules, resulting in toxicity.
Toxicity falls into two primary categories: local and systemic.
Local toxicity appears at the exposure site, such as protein denaturation caused by caustic substances.
In contrast, systemic toxicity requires the toxic agent's absorption and distribution,...