身体圆度指数和类风湿性关节炎风险:来自NHANES 1999至2020年的证据
Xin Huang1, Wenzhuo Huang2, JingJie Li3
1Department of Orthopedics, Hangzhou Lin'an Traditional Chinese Medicine Hospital, Hangzhou, Zhejiang Province, China.
Medicine
|December 30, 2025
概括
较高的身体圆度指数 (BRI) 与风湿性关节炎 (RA) 风险增加有关. 这一发现表明,BRI可能有助于识别需要RA早期干预的人.
科学领域:
- 类风湿病学 类风湿病学
- 公共卫生 公共卫生
- 生物统计学 生物统计学
背景情况:
- 类风湿性关节炎 (RA) 是一种慢性自身免疫性疾病,影响关节.
- 确定RA的新风险因素和预测标志物对于早期干预至关重要.
- 身体成分指标超出了传统的指标,比如BMI,需要对其与RA相关性进行调查.
研究的目的:
- 调查身体圆度指数 (BRI) 与患类风湿性关节炎 (RA) 的风险之间的关联.
- 探索BRI作为RA风险分层的实际标志物的潜力.
主要方法:
- 这是一项采用国家健康和营养检查调查 (1999-2020) 对33239名成年人数据的横截面研究.
- 通过自我报告确定RA状态;BRI用标准公式计算.
- 权重后勤回归和受限立方线模型分析了BRI-RA关系,并调整了共变量.
主要成果:
- 在较高的BRI和增加的RA风险之间发现了显著的积极关联 (aOR=1.255每单位增加,P<.001).
- 观察到BRI和RA风险之间的非线性剂量反应关系 (P<.05).
- 预测RA的BRI曲线下的面积 (AUC) 为0.793,表明良好的歧视力.
结论:
- 身体圆度指数升高与非线性风险较高的类风湿性关节炎独立相关.
- "一带一路"展示了作为一种有价值,实用的工具,用于RA风险评估和指导早期干预策略的潜力.
- 对像BRI这样的身体组成指标的进一步研究可能会增强我们对RA病原和预防的理解.
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