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出生体重与肺功能的关联以及肠道微生物群的调解作用:STROBE二步门德尔随机化研究

Limin Cao^1,2, Yaochen Zhang³, Yun Li¹

¹Department of Pediatrics, Shanxi Medical University, Taiyuan, China.

|December 30, 2025

概括

低出生体重 (LBW) 与成人肺功能降低有关. 肠道细菌部分调解了这种关联,为预防LBW个体肺部功能障碍提供了洞察力.

科学领域:

肺部医学肺部医学
微生物组研究微生物组研究
遗传学是一个遗传学.

背景情况:

低出生体重 (LBW) 越来越被认为是成年期肺功能受损的危险因素.
早期生活因素与长期呼吸系统健康之间的复杂相互作用需要进一步研究.
肠道微生物组在调解LBW对肺部健康的影响方面的潜在作用尚未完全理解.

研究的目的:

研究基因决定的出生体重与成年人肺功能之间的关联.
探索肠道微生物群在LBW和成人肺功能缺陷之间的关系中的调解作用.

主要方法:

使用全基因组关联研究总结数据进行双样本门德尔随机化 (MR) 分析.
应用各种MR方法,包括逆方差加权,MR-Egger,加权中位数,简单模式和加权模式.
两步MR调解分析,以评估特定肠道细菌种群的影响.

主要成果:

在出生体重和关键肺功能参数之间发现了显著的遗传关联:强迫的生命能力,1秒内强迫的呼吸量 (FEV1),FEV1/强迫的生命能力比率和肺体积.
调解分析显示,特定的肠道微生物群,包括g_Blautia,s_Subdoligranulum_unclassified和s_Ruminococcus_obeum,部分调解LBW对成人肺功能的影响.
这些发现突出了LBW和成人肺功能下降之间的重要联系,肠道微生物组成的显著贡献.

结论:

低出生体重与成人肺功能受损有显著的关联.
肠道微生物群在从LBW到肺功能减弱的途径中发挥着部分调解作用.
准肠道微生物群可能为预防或减轻低出生体重的个体肺功能缺陷提供新的策略.

关键词:

门德尔的随机化出生的体重出生时的体重.我们的肠道微生物群.肺肺肺肺肺肺肺肺肺肺病学肺病学肺病学肺病学

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