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肠道微生物群,血代谢物和肝细胞癌之间的因果关系:一个调解的门德尔随机化研究

Xiaoning Zeng¹, Sirou Li¹, Xiaoli Xiong²

¹Department of Clinical Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital and Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China.

|December 30, 2025

概括

像Coprococcus2这样的肠道细菌可能通过改变酸盐水平来降低肝癌风险,而Ruminococcus2可能通过影响特定脂肪来增加风险. 这项研究澄清了肠道微生物群.

科学领域:

肠道微生物群和新陈代谢
肝细胞癌 (HCC) 病因肝细胞癌 (HCC) 病因学
人类遗传学和流行病学

背景情况:

观察性研究表明,肠道微生物群和肝细胞癌 (HCC) 之间存在联系.
精确的因果关系和血代谢产物的作用仍然不清楚.
了解这些相互作用对于预防和治疗HCC至关重要.

研究的目的:

调查肠道微生物群和HCC之间的因果关系.
量化血代谢产物在这种关系中的调解作用.
为了确定HCC的潜在生物标志物和治疗点.

主要方法:

使用双样本的门德尔随机化 (MR) 分析与全基因组关联研究数据.
分析了211种肠道微生物群,1400种血代谢物和HCC之间的关系.
使用逆方差加权 (IVW) 和贝叶斯加权MR进行因果推理和稳定性检查.

主要成果:

科普罗科克2属通过增加酸盐与EDTA的比率来降低HCC风险的因果作用,调解了7.77%的效果.
Ruminococcus2属因果关系与增加的HCC风险有关,因为降低了1-oleoyl-2-linoleoyl-GPE水平,介导了5.21%的效果.
没有检测到显著的异质性或质性;在MR方法中,结果是强大的.

结论:

在特定的肠道微生物群 (Coprococcus2,Ruminococcus2) 和HCC风险之间建立了因果关系.
确定了血代谢物 (酸盐与EDTA的比率,1-oleoyl-2-linoleoyl-GPE) 作为重要的介质.
结果表明新的生物标志物和针对性策略,通过肠-代谢物-肝轴调节来诊断和干预HCC.

关键词:

门德尔的随机化这种因果关系是因果关系.我们的肠道微生物群.肝细胞癌是肝细胞癌.调解者效应是一种调解效应.血代谢产物中的血代谢产物

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