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Updated: Jan 7, 2026

An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses
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An Orthotopic Model of Serous Ovarian Cancer in Immunocompetent Mice for in vivo Tumor Imaging and Monitoring of Tumor Immune Responses

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基于EPI-SauriCas9的小鼠卵巢癌模型回顾了患者的pten删除

Wutao Chen1,2, Pengju He3, Ling Ding4

  • 1Department of Obstetrics and Gynecology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.

Communications biology
|December 30, 2025
PubMed
概括

研究人员开发了一种新的小鼠模型 (MEPP) 来研究带有PTEN和TP53删除的卵巢癌,这对于理解这种致命的妇科恶性瘤和测试新疗法至关重要.

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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