发酵大豆蛋白梅拉德产品通过TNF-α抑制和肠骨轴调节在经过卵巢切除的小鼠中防止骨质损失
Hyun Jin Bae1, Jae Yeon Joung2,3, Hyo Su Choi1
1Department of Food and Biotechnology, Korea University, Sejong 30019, Republic of Korea.
Journal of microbiology and biotechnology
|December 30, 2025
概括
来自发酵大豆蛋白 (MRPF) 的梅拉德反应产物 (MRPs) 显示出显著的骨保护作用. MRPF缓解炎症并改善肠道健康,为绝经后骨质疏松症管理提供了潜力.
科学领域:
- 营养科学 营养科学
- 免疫学 免疫学 免疫学
- 微生物学 微生物学
背景情况:
- 绝经后的骨质疏松症与炎症和肠道失调有关.
- 来自大豆蛋白的梅拉德反应产物 (MRPs) 可能具有生物活性.
- 发酵MRP可以提高它们的功能性质.
研究的目的:
- 通过使用Lacticaseibacillus rhamnosus IM18.研究孤立的大豆蛋白MRPs及其发酵产品 (MRPF) 的骨保护作用.
- 为了评估MRPF的抗炎和抗骨质结核性潜力.
- 探索MRPF对肠道微生物群和肠道屏障功能的影响.
主要方法:
- 在体外试验中,使用RAW264.7细胞刺激了脂多糖和RANKL.
- 在使用卵巢切除小鼠模型的体内研究.
- 对细胞因子表达,骨质蛋白蛋白水平和肠道屏障基因表达的分析.
- 肠道微生物群的分析和生物活性的识别.
主要成果:
- 与MRP相比,MRPF表现出增强的抗氧化和抗炎活性.
- 在体外和体内,MRPF抑制了骨质细胞分化,并阻止了骨的再吸收.
- MRPF调节了肠道微生物群,减少了促炎细胞因子,并恢复了肠道屏障的完整性.
- 在MRPF中发现了28种生物活性.
结论:
- MRPF表现出显著的抗骨质结晶和骨保护作用.
- MRPF可以缓解炎症并维持肠道平衡.
- 对于治疗绝经后骨质疏松症而言,MRPF具有作为一种功能性食品成分的潜力.
相关概念视频
Bone Disorders
5.0K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
5.0K
Osteoclasts in Bone Remodeling
3.8K
Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
3.8K
TGF - β Signaling Pathway
10.4K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
10.4K
Hormones and Bone Tissue
3.6K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
3.6K
Protein Digestion
110.2K
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
110.2K
Essential Minerals for Bone Health
5.9K
The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
Calcium and Phosphorus
Calcium is a critical component of bones, especially in the form of calcium phosphate and calcium carbonate. Since the body cannot make calcium, it must be obtained from the diet. However, calcium cannot be absorbed from the small intestine without...
5.9K


