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VEGF作为外周动脉疾病患者主要不良事件的预测因子 - - 一项探索性研究
Hamzah Khan1,2, Sayyid Frljuckic1, Abdelrahman Zamzam1
1Division of Vascular Surgery, St. Michael's Hospital, Toronto, ON, M5B 1W8, Canada.
Journal of thrombosis and thrombolysis
|December 30, 2025
概括
血管内皮生长因子-A (VEGF) 与周围动脉疾病 (PAD) 患者的重大不良心血管事件 (MACE) 和重大不良肢体事件 (MALE) 的风险较高有关. 较高的VEGF水平表明MACE和MALE风险增加,有助于PAD患者风险分层.
科学领域:
- 心血管医学 心血管医学
- 血管生物学 血管生物学
- 生物标志物研究 生物标志物研究
背景情况:
- 周围动脉疾病 (PAD) 是一种显著的动脉样硬化的疾病,其特征是周围动脉狭窄.
- 虽然血管新生可以在PAD中有益,但它也可能导致不良的长期心血管结果.
- 血管内皮生长因子-A (VEGF-A) 已与PAD的病理生理学有关.
研究的目的:
- 调查血VEGF水平与PAD患者中主要不良心血管事件 (MACE) 和主要不良肢体事件 (MALE) 的发生率之间的关联.
- 评估VEGF作为PAD患者风险分层的生物标志物的潜力.
主要方法:
- 在300名被诊断患有PAD的患者中量化了VEGF血水平 (ABI<0.9).
- 患者被监测MACE (心肌梗塞,中风,心血管死亡) 和MALE (四肢缺血进展,手术干预,重新封闭,截肢).
- 应用多变量Cox比例危险回归和Bonferroni校正来分析VEGF与事件风险之间的关联.
主要成果:
- 在调整心血管风险因素后,VEGF独立地与MACE (HR 1.26,p < 0.001) 和MALE (HR 1.176,p = 0.001) 的风险增加有关.
- 在VEGF中每增加1个单位,MACE风险上升26.0%,MALE风险上升17.6%.
- 这些发现突显了VEGF水平与PAD中心血管和四肢不良事件之间的显著关联.
结论:
- 血VEGF水平与PAD患者中MACE和MALE的风险增加显著相关.
- 在患有PAD的个体中,VEGF可以作为一个有价值的生物标志物来分层心血管和四肢事件风险.
- 进一步的研究可以探索针对PAD管理中的VEGF的治疗策略.
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