在肯尼亚测试基于药房的不同模式的艾滋病毒暴露前后预防启动和管理:集群随机对照试验的协议
Tabitha Kareithi1, Stephanie D Roche2, Allison Meisner2
1Partners in Health Research and Development, Center for Clinical Research, Kenya Medical Research Institute, Nairobi, Kenya.
Trials
|December 30, 2025
概括
这项研究评估了私人药房的艾滋病毒预防,将药房主导的暴露前预防 (PrEP) 和暴露后预防 (PEP) 与标准诊所转诊进行比较. 结果将指导将药房纳入艾滋病毒预防战略.
科学领域:
- 公共卫生 公共卫生
- 预防艾滋病毒 预防艾滋病毒
- 医疗保健服务研究 医疗服务研究
背景情况:
- 私人药房在肯尼亚很常见,但对于艾滋病毒预防服务,如暴露前预防 (PrEP) 和暴露后预防 (PEP),其利用率不足.
- 与临床推相比,私人药房发起和管理PrEP/PEP的有效性尚不清楚.
- 这项研究旨在为预防艾滋病毒的公共私人伙伴关系提供信息.
研究的目的:
- 将通过私人药房提供的艾滋病毒暴露前和暴露后预防 (PrEP/PEP) 与标准诊所转诊相比较.
- 评估药店PrEP/PEP交付的不同模式,包括客户付费,实施者付费和辅导员支持的模式.
- 评估药店提供的PrEP/PEP的可行性,可接受性和成本效益.
主要方法:
- 肯尼亚的一项60家药房,四臂集群随机对照试验.
- 药房被随机分为:客户持续提供PrEP/PEP,实施者持续提供,实施者持续提供辅导员支持,或标准转诊 (控制).
- 主要结局包括PrEP启动和在60天后继续使用;次要结局评估PEP启动,在60天和270天后继续使用PrEP/PEP,以及实施结果.
主要成果:
- 这项试验正在进行中,首次招生于2023年6月26日.
- 主要分析将每个干预臂与对照组进行比较.
- 二次分析将相互比较干预武器,评估客户和提供商对实施结果的看法.
结论:
- 该试验将提供证据,证明使用私人药房提供PrEP和PEP的好处.
- 它将确定基于药房的不同交付模式的相对有效性,包括由客户或实施者补贴和辅导员支持的药房.
- 预计这些发现将为政策和战略提供信息,通过私人药房扩大艾滋病毒预防服务.
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