关节与药物相关的骨髓缩:来自韩国多学科工作组的基于证据的2025年立场声明
Jin-Woo Kim1, Sung-Hye Kong2, Jae-Young Kim3
1Department of Oral and Maxillofacial Surgery, Ewha Womans University College of Medicine, Seoul, Korea.
Journal of the Korean Association of Oral and Maxillofacial Surgeons
|December 30, 2025
概括
与药物相关的下巴骨硬化 (MRONJ) 准则已为韩国更新. 新的建议侧重于早期检测,药物特定的预防性药物假期和积极的手术干预,以改善患者的治疗结果.
科学领域:
- 口腔和牙面部外科手术
- 内分泌学 在内分泌学.
- 骨的新陈代谢 骨的新陈代谢
背景情况:
- 与药物相关的下巴骨硬化 (MRONJ) 是一个日益严重的全球问题,原因是人口老龄化和抗吸收药物的使用增加.
- 对于MRONJ管理的现有临床指南需要根据特定的医疗保健环境进行调整.
研究的目的:
- 制定基于证据的,针对韩国预防,诊断和管理MRONJ的具体临床指南.
- 提供来自五个韩国学术协会的多学科工作组的共识声明.
主要方法:
- 综合文献综述. 这是一个全面的文献综述.
- 三轮正式调查,巩固有关MRONJ有争议的话题的专家意见.
- 由一个多学科工作组制定立场陈述.
主要成果:
- 修订了MRONJ的诊断标准,包括基于临床/放射性证据的早期诊断.
- 倡导保持0阶段的早期检测和预防性干预.
- 药物特定的预防性药物假期建议 (例如,口服双酸盐2个月,外科手术后的3至4个月).
结论:
- 该指南强调了所有MRONJ阶段的早期和积极的手术干预,证明了优越的长期结果.
- 为治疗性药物假期提供了一个框架,平衡下巴愈合与骨折风险.
- 该立场声明旨在在韩国标准化MRONJ护理,减少混乱,并改善患者的治疗结果.
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