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优化针对抗体和药物结合物的基于体型的剂量方法

Andrew B SyBing1, Diane D Wang1

  • 1Pfizer Oncology Early Stage Development, Clinical Pharmacology, San Diego, California, USA.

Clinical pharmacology and therapeutics
|December 30, 2025
PubMed
概括

优化抗体-药物合物 (ADC) 剂量至关重要. 使用调整的理想体重 (AIBW) 或身体表面积 (BSA) 与剂量上限提高精度,特别是当清除缩放不理想时.

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