益生菌和改善癌症治疗中的生活质量
Himani Muniyal Jheetay1, Nikhil Menia2, Kishore Chandra Thakur3
1Department of Biochemistry, GEIMS, Dehradun, Uttrakhand, India.
Bioinformation
|December 30, 2025
概括
益生菌,特别是乳酸菌,改善了接受治疗的癌症患者的生活质量. 患者在化疗和放射治疗期间经历了更好的情绪平衡,认知清晰度和减少胃肠道毒性.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 心理学 心理学 心理学
背景情况:
- 化疗和放射治疗等癌症疗法通常会导致胃肠道毒性和精神疲劳,显著降低患者的生活质量.
- 肠-大脑轴在调解癌症治疗对身体和精神健康的影响方面发挥着至关重要的作用.
研究的目的:
- 调查乳杆菌益生菌补充剂对接受治疗的癌症患者生活质量的影响.
- 评估益生菌在减轻与癌症治疗相关的胃肠道毒性和精神疲劳方面的有效性.
主要方法:
- 进行了一项观察性研究,涉及接受化疗和/或放射治疗的癌症患者.
- 患者接受了Lactobacillus益生菌补充剂,结果在6周的时间内进行了比较.
- 生活质量指标包括角色功能,情绪平衡和认知清晰度. 还监测了胃肠道毒性和洛佩拉米德的使用.
主要成果:
- 服用Lactobacillus益生菌的患者在6周后在角色功能 (p=0.016),情绪平衡 (p=0.020) 和认知清晰度 (p=0.037) 方面表现出统计学上显著的改善.
- 在益生菌组中观察到腹严重程度显著降低 (p<0.001).
- 益生菌组中需要救援洛佩拉米德的患者较少 (24%对44%,p=0.034).
结论:
- 乳酸菌益生菌可以帮助癌症患者更好地适应治疗相关的压力.
- 益生菌补充似乎在化疗和放射治疗期间保护肠-大脑轴,从而改善患者的生活质量.
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