解读肝脏困境:疟疾治疗后的一例急性肝炎病例
Sydney Lovrien1, Erin Quist2,3, Dayana Maita Coronel4
1Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, South Dakota, USA, sdstate.edu.
Case reports in gastrointestinal medicine
|December 30, 2025
概括
这项案例研究突出了55岁女性罕见的疟疾与急性肝炎的呈现. 她的症状最终归因于药物诱导的抗疟疾药物的肝损伤.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 临床病例报告 临床病例报告
背景情况:
- 疟疾,特别是*P. falciparum*感染,是一种严重的疾病,但很少引起急性肝炎.
- 肝炎和黄是疟疾的罕见表现,使得诊断具有挑战性.
研究的目的:
- 报告患有*P. falciparum*疟疾的患者罕见的急性肝炎病例.
- 在疟疾患者中调查胆固醇性肝炎和透氨炎的原因.
- 为了区分与疟疾相关的肝损伤与其他原因,如药物诱导的肝损伤.
主要方法:
- 一个55岁的非洲妇女在喀麦隆接受疟疾治疗的案例报告.
- 临床评估,包括肝活检,以评估肝病理.
- 诊断工作包括为检测疟疾寄生虫的连续血液涂抹.
- 在17个月内监测肝酶和胆红素水平.
主要成果:
- 患者出现了黄和肝酶升高,与胆固醇性肝炎一致.
- 疟疾诊断因血液涂抹结果不一致而复杂化.
- 肝酶和胆红素在17个月内正常化,没有额外的疟疾治疗.
- 这些发现最终归因于抗疟药物引起的药物诱导性肝损伤.
结论:
- 急性肝炎是疟疾的一个不寻常的表现.
- 在出现肝炎的疟疾患者中,应考虑药物诱导的肝损伤,特别是在抗疟疾治疗后.
- 仔细监测和差异诊断对于管理复杂的疟疾病例至关重要.
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