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用伊特拉科纳装载的聚烯酸纳米粒子凝用于增强通过皮肤传递:开发,表征和体外评估

Sajjad Hussain^1,2, Nadia Shamshad Malik¹, Ume Ruqia Tulain³

¹Faculty of Pharmacy, Capital University of Science and Technology, Islamabad, Pakistan.

International journal of nanomedicine

|December 30, 2025

概括

碳聚凝中的聚烯酸 (PCL) 纳米颗粒增强了通过皮肤输送伊特拉可纳 (ITZ). 这种配方改善了药物释放和皮肤透,为抗真菌治疗提供了有前途的方法.

科学领域:

制药科学制药科学
材料科学材料科学材料科学
生物医学工程生物医学工程

背景情况:

伊特拉科纳 (ITZ) 是一种BCSII类的抗真菌药物,具有较差的水溶性和可变的口服生物可用性,这给配方带来了挑战.
通过皮肤递送药物提供了一种替代途径,以克服口服生物可用性问题并提高治疗疗效.

研究的目的:

开发和表征聚烯 (PCL) 纳米颗粒,以增强通过皮肤输送伊特拉可纳 (ITZ).
为提升皮肤透度和持续释放药物的ITZ装载PCL纳米粒子凝配制.

主要方法:

纳米颗粒使用修改的纳米沉方法制备,优化的配方被纳入碳烯凝中.
特性包括颗粒大小,PDI,泽塔潜力,封装效率 (EE),体外释放,体外透,皮肤刺激和稳定性研究.

主要成果:

优化的PCL纳米粒子 (F2) 呈现出有利的特征:154.6nm大小,0.378PDI,-10.7mV泽塔电位,和88.4%的EE.
凝配方在pH值为5.5和7.4时显著增强透皮透 (增加了2.32倍) 和持续的药物释放 (24小时内80.41-94.34%).
该配方在三个月内是不刺激和稳定的,ITZ在无形状态下证实没有相互作用.

结论:

一种生物相容的PCL基凝已成功开发,用于增强伊特拉科纳的通过皮肤输送.
该配方提供持续的药物释放和改善的皮肤透性,代表ITZ透皮治疗的有效策略.

关键词:

在BCSII类中,BCS是II类.这是伊特拉可纳.纳米颗粒是一种纳米粒子.响应pH的释放反应聚卡普罗拉克托尼是一种多重的产物.通过皮肤透.通过皮肤传递的传递.

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