贝瓦西祖马布相关的肠道穿孔导致内脏剥离
Maziar Fazel Darbandi1, Garrett Johnson1, Krista Hardy1
1Department of Surgery, University of Manitoba, Winnipeg, CAN.
用于转移性直肠癌的贝瓦西祖马布很少会导致胃肠道穿孔. 这一案例突出显示了一名患者经历了小肠切除,通过结肠架位孔穿孔,需要手术干预和恢复.
科学领域:
- 在瘤学瘤学.
- 胃肠病学 胃肠病学
- 手术瘤学手术瘤学
背景情况:
- 贝瓦西祖马布是一种单克隆抗体,向血管内皮生长因子 (VEGF),抑制固体瘤中的血管生成.
- 它在转移性结直肠癌 (CRC) 管理中有效,当与基于甲的化疗相结合.
- 胃肠道穿孔是贝瓦西祖马布治疗的罕见但已知的并发症.
研究的目的:
- 报告一种罕见的小肠内脏通过结肠静脉切开部位穿孔的情况.
- 讨论贝瓦西祖马布和半体对这种并发症的潜在贡献.
- 为了说明这种患者出现的手术管理和康复.
主要方法:
- 一个70多岁的男性患者的病例报告,患有转移性直肠癌,接受了贝瓦西祖马布治疗.
- 通过穿孔的结肠管部部位进行小肠切除的呈现,与半体有关.
- 描述新出现的手术干预,包括切除,修复和结肠直肠创建.
主要成果:
- 患者接受了小肠切除和结肠穿孔的紧急手术.
- 外科手术包括切除缺血性肠道,穿孔结肠,修复和新结肠形成.
- 患者康复良好,并在手术后两周出院,继续接受缓性化疗.
结论:
- 这一案例强调了在接受贝瓦西祖马布治疗的患者中,胃肠道穿孔的罕见风险,特别是在结肠直肠切口部位.
- 慢性半腹和贝瓦西祖马布治疗之间的相互作用可能会导致这种严重的并发症.
- 在这种情况下,迅速的手术干预对于控制肠道内脏和穿孔至关重要,从而允许继续进行瘤治疗.
更多相关视频
06:15Tumor Treating Field Therapy in Combination with Bevacizumab for the Treatment of Recurrent Glioblastoma
Published on: October 27, 2014
04:01Indocyanine Green-Guided Intraoperative Imaging to Facilitate Video-Assisted Retroperitoneal Debridement for Treating Acute Necrotizing Pancreatitis
Published on: September 8, 2022
相关概念视频
Esophageal Perforation-I: Introduction
The location of esophageal perforation can vary, occurring anywhere along the esophagus....
Esophageal Perforation-II: Clinical Manifestations and Management
Clinical Manifestations:
Inflammatory Bowel Disease I: Ulcerative Colitis
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory Bowel Disease V: Surgical Management
Here are some common surgical interventions for IBD:
Endoscopic Procedures II: Colonoscopy
