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Updated: Jan 7, 2026

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
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经二元化BRS3-EP3的激活通过合Gαs蛋白质抑制了黑色素瘤细胞迁移

Zeyuan Wang1,2, Lehao Wu1,2, Miao Guo2

  • 1Shanghai Frontiers Science Center of Drug Target Identification and Delivery, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.

Fundamental research
|December 30, 2025
PubMed
概括

庞贝素受体亚型-3 (BRS3) 和E-prostanoid 3受体 (EP3) 形成二次体,改变信号通路. 这种相互作用涉及Gαs蛋白,P38酸化和F-actin重组,最终抑制黑色素瘤细胞迁移.

关键词:
庞贝素受体亚型-3细胞迁移 细胞迁移模度化 (Dimerization) 是一个过程.对于E-prostanoid 3受体来说,这是一个很好的选择.黑色素瘤是一种黑色素瘤.

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