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在移植接受者的抗PD-1诱导的球状皮虫病中

Ghassan Barnawi¹, Abby Johanna Kpata², Raghad Aldibane¹

¹Division of Dermatology, McGill University, Montreal, QC, Canada.

SAGE open medical case reports

|December 30, 2025

概括

免疫检查点抑制剂可以触发状皮虫,一种罕见的皮肤反应. 这个案例详细介绍了它在移植患者中发生的情况,强调了在这样复杂的场景中谨慎管理.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
皮肤病学皮肤病学

背景情况:

免疫检查点抑制剂 (ICI),特别是抗PD-1药物,与型皮虫 (BP) 有关.
高血压是一种显著的免疫相关不良事件 (irAE).
接受免疫抑制的移植患者对ICI治疗提出了独特的挑战.

研究的目的:

报告ICI诱导的型尾虫病例在移植接受者身上.
在免疫抑制的背景下讨论这种irAE的管理.
突出需要个性化护理来管理移植患者的irAEs.

主要方法:

一个74岁的脏移植接受者的病例报告,患有复发性皮肤状细胞癌.
治疗包括塞米普利马布和潘布罗利祖马布 (抗PD-1药物).
通过组织学和直接免疫光检测证实了型皮虫的诊断.

主要成果:

在初始ICI暴露后23个月,在重新开始服用 pembrolizumab后4周后,发病了型皮虫.
患者呈现出和紧张的球形.
使用口服普得尼松和局部类固醇治疗的疾病管理在逐渐减少后出现复发.

结论:

由ICI诱导的球状皮是移植患者中显著的irAE.
管理需要采用多学科的方法,考虑ICI治疗和免疫抑制.
在这种人群中,个性化策略对于管理自身免疫性毒性至关重要.

关键词:

这种类型的类皮虫 (Bullus pemphigoid) 是一种皮肤状细胞癌瘤免疫检查点抑制剂免疫检查点抑制剂与免疫相关的不良事件.进行移植.

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