相关实验视频
Updated: Jan 7, 2026

07:02
In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
Published on: August 23, 2019
7.7K
每天肌肉内输入levothyroxine治疗耐阻性甲状腺功能低下症和吸收不良症
Thanh D Hoang1,2, Thuy D Le1, Phong N Truong1,2
1Division of Endocrinology, Department of Medicine, Walter Reed National Military Medical Center, Bethesda, Maryland.
AACE endocrinology and diabetes
|December 30, 2025
概括
对于抗甲状腺功能低下,难以接受口服勒沃西 (LT4) 的患者来说,注射式LT4提供了一个可行的替代方案. 本案例报告详细介绍了使用每日肌内 (IM) LT4治疗持续性甲状腺功能低下症的成功治疗方法,使甲状腺刺激激素 (TSH) 水平正常化并消除症状.
科学领域:
- 内分泌学 在内分泌学.
- 药理学 药理学是指药理学的学科.
- 内部医学 内部医学
背景情况:
- 利沃甲状腺素 (LT4) 单疗法是甲状腺功能低下症的标准.
- 当标准治疗无效时,可以考虑替代疗法.
- 胃绕道手术会影响甲状腺激素的吸收.
研究的目的:
- 报告一种不耐药性甲状腺功能低下症的病例,该病例已成功地用肌内 (IM) 利沃西 (LT4) 治疗.
- 突出IM LT4作为患有吸收不良问题的患者的替代疗法的潜力.
主要方法:
- 一名55岁的女性患有哈西莫托的甲状腺炎经历了胃旁路手术后持续的甲状腺功能低下症.
- 多次口服LT4和干燥甲状腺疗法未能使甲状腺刺激激素 (TSH) 水平正常化.
- 甲状腺激素吸收测试显示,口服生物可用性显著降低.
- 治疗始于每日肌内注射 (IM) LT4 (100毫克).
主要成果:
- 尽管患者接受了各种口服甲状腺激素治疗,但患者表现出持续的甲状腺功能低下,TSH升高,自由甲状腺素低.
- 吸收测试显示口服levothyroxine和干燥的甲状腺提取物的生物可用性较差.
- 每日IM LT4的使用导致TSH水平正常化.
- 所有报告的甲状腺功能低下症症状都在IM LT4治疗中消失.
结论:
- 肌肉内注射 (IM) 利沃西 (LT4) 是患有甲状腺功能低下症和口服吸收受损的患者的潜在治疗选择.
- 这是第一个案例报告,证明了IM LT4耐药性甲状腺功能低下症的每日门诊治疗成功.
- 需要进一步的研究来探索IM LT4在治疗甲状腺功能低下症中的有效性和安全性.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
7.0K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
7.0K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
604
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
604
Myasthenia Gravis: Overview and Treatment
2.7K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.7K
Insulin: Dosing Regimen and Adverse Effects
644
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
644
The Thyroid Gland
6.5K
The thyroid gland is a small, butterfly-shaped gland located in the neck and covers the anterior surface of the trachea. The gland has two lateral lobes connected by a thin tissue mass called the isthmus. Internally, each lobe comprises many small spherical structures known as thyroid follicles, surrounded by a network of blood vessels.
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
The follicles have a central cavity lined by simple cuboidal to squamous epithelial cells called follicular cells. These cells produce the glycoprotein...
6.5K
Functions of Thyroid Hormones
4.9K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
4.9K

