在慢性鼻炎与鼻息肉中,早期与延迟的鼻手术后的喘结果
Jamie R Oliver1, Christopher L Crafton2, Easton W Attwood1
1Department of Otolaryngology-Head and Neck Surgery, Kansas University Medical Center, Kansas City, Kansas, USA.
International forum of allergy & rhinology
|December 30, 2025
概括
早期内镜外科手术治疗带有鼻息肉的慢性鼻炎可能会改善喘的结果. 接受早期手术的患者出现了较少的喘恶化,并减少了对长效β2激动剂和生物制剂的需求.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 肺部病理学 肺部病理学
- 免疫学 免疫学 免疫学
背景情况:
- 具有鼻息肉的慢性鼻炎 (CRSwNP) 经常与喘同时发生.
- 透视鼻手术 (ESS) 可以缓解喘症状,但最佳时间仍在争论中.
- 早期 (<6个月) 与晚期 (1-3年) ESS 对喘进展的影响尚不清楚.
研究的目的:
- 调查早期ESS和改善喘结果之间的关联.
- 为了比较喘严重程度,恶化和药物使用后早期与晚期ESS.
- 为了确定早期手术干预是否会改变CRSwNP患者的长期喘轨迹.
主要方法:
- 使用TriNetX研究网络进行的回顾性队列研究.
- 接受ESS的成年CRSwNP患者被分为早期 (≤6个月) 或晚期 (1-3年) 手术组.
- 倾向性得分匹配 (1:1) 在人口统计学,基线喘严重程度和药物使用方面平衡小组,并进行5年结果分析.
主要成果:
- 早期的ESS与中度和重度持久性喘风险降低有关.
- 接受早期手术的患者出现了较少的喘恶化.
- 早期的ESS与长效β2-激动剂 (LABAs),皮质类固醇和生物药物的利用率下降有关.
结论:
- 在CRSwNP患者中,早期的ESS与更好的喘控制和减少疾病进展有关.
- 及时的外科干预可能会改变CRSwNP患者喘的自然过程.
- 早期的ESS可能会降低CRSwNP患者的长期喘治疗负担.
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