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在帕金森病中,GBA1与 lysosomal 功能障碍和炎症的相互作用

Ruochen Wang1, Taku Hatano1, Nobutaka Hattori1

  • 1Department of Neurology, Juntendo University, Tokyo, Japan.

Neural regeneration research
|December 30, 2025
PubMed
概括

帕金森病的风险是显著增加在葡萄糖大脑酶 (GBA1) 基因的突变. 这些GBA1变异导致神经炎症和α-synuclein聚合,推动疾病的进展.

关键词:
帕金森病是帕金森病的一种.自-溶酶体通路自 - 溶酶体通路溶酶体功能障碍 溶酶体功能障碍微生物组-肠道-大脑轴线粒体中的线粒体.神经退行症的神经退行症神经炎症是一种神经炎症.精准医学是一门精准医学.α-synuclein 是一种同核蛋白.

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