在急性尾炎的手术内样本中细菌学概况和抗菌素耐药性:三年后期分析
Quanwei Wang1, Xiao Xu1, Weiwei Ma1
1Department of General Surgery, Pinghu Second People's Hospital, Pinghu, China.
ANZ journal of surgery
|December 30, 2025
概括
格拉姆阴性细菌,特别是大肠杆菌,是尾炎感染的主要原因. 碳烯和阿米卡辛仍然是有效的治疗方法,而阿莫西西林显示出高耐药性,指导经验性治疗选择.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 临床药房 临床药房
背景情况:
- 尾炎是一种常见的手术紧急情况.
- 术内培养对于识别病原体和指导治疗至关重要.
- 抗生素耐药性模式需要定期监测.
研究的目的:
- 为了确定急性尾炎的细菌学概况.
- 评估孤立病原体的抗微生物敏感性模式.
- 为了告知尾炎的经验性抗生素治疗.
主要方法:
- 从2021-2023年对110名患者的回顾性分析.
- 培养和识别98个手术内质样本.
- 根据CLSI指南,对20种抗生素进行抗菌敏感性测试.
主要成果:
- 格拉姆阴性细菌构成了91.84%的分离物,其中大肠杆菌 (Escherichia coli) (71.43%) 是主要物种.
- 大肠杆菌对阿莫西西林 (94.29%) 呈现出高耐药性,但对美罗,伊米和阿米卡仍然保持敏感性.
- 克莱布西拉肺炎和Pseudomonas aeruginosa也对几种常见的抗生素表现出耐药性,卡巴和阿米卡保持了广泛的疗效.
结论:
- 格拉姆阴性肠道细菌,特别是大肠杆菌,是尾感染的主要病原体.
- 碳烯和阿米卡辛是高度有效的,而阿莫西西林显示出显著的耐药性.
- 皮佩拉西林-塔扎巴克坦是一种可行的一线选择;卡巴胺应该保留给严重病例或耐药生物.
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