Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Fungal Phylum Ascomycota01:28

Fungal Phylum Ascomycota

954
Phylum Ascomycota, a major division within the subkingdom Dikarya, comprises a diverse range of fungal species, including both unicellular yeasts and filamentous molds such as Aspergillus and Penicillium. These fungi thrive in a variety of habitats, from aquatic ecosystems to terrestrial environments, playing crucial ecological and economic roles.Morphology and ReproductionThe defining characteristic of Ascomycetes, commonly referred to as sac fungi, is the ascus—a sac-like structure that...
954

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Multiomics studies reveal how ambient temperature changes govern cellular responses of Chlamydomonas.

The Plant cell·2026
Same author

A Revised Model for Muscarine Biosynthesis Involving Lysine Trimethylation.

Angewandte Chemie (International ed. in English)·2026
Same author

Specific and Multi-Product Clade I and Clade IV Sesquiterpene Synthases Contribute to the Psilocybe cubensis Volatilome.

Chembiochem : a European journal of chemical biology·2026
Same author

Advances in molecular tools for elucidating nucleic acid biology in fungal pathogens.

microLife·2026
Same author

Anti-Inflammatory Lindolin Alkaloids Repress the Transcription of the Microsomal Prostaglandin E<sub>2</sub> Synthase-1 Gene in Macrophages.

Journal of natural products·2026
Same author

Facultative heterochromatin mediated by core and accessory chromosome-encoded H3K27-specific methyltransferases controls virulence in a fungal phytopathogen.

Nucleic acids research·2026

相关实验视频

Updated: Jan 7, 2026

Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the &#945;-amylase Inhibitor from Lablab purpureus L.
09:21

Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.

Published on: February 15, 2019

11.0K

在高压条件下用转基因阿斯伯吉卢斯尼杜兰斯生产psilocybin.

Sophie Weiser1,2, Sidney Jung1, Bettina Bardl1

  • 1Bio Pilot Plant, Leibniz Institute for Natural Product Research and Infection Biology-Hans Knöll Institute, Jena, Germany.

Biotechnology and bioengineering
|December 30, 2025
PubMed
概括

研究人员开发了一种生物技术方法,使用Aspergillus nidulans生产psilocybin. 这种高效的工艺实现了高产量,可能支持用于精神病治疗的药物应用.

关键词:
有氧生物过程有氧生物过程.有丝状真菌的真菌.印类类化合物 印类类化合物压力过大 压力过大这种药物是psilocybin.动式储反应堆的反应堆粘性文化是一种粘性文化.

更多相关视频

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles
10:51

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles

Published on: March 15, 2012

19.7K
Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software
11:30

Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software

Published on: July 24, 2021

4.2K

相关实验视频

Last Updated: Jan 7, 2026

Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the &#945;-amylase Inhibitor from Lablab purpureus L.
09:21

Inhibition of Aspergillus flavus Growth and Aflatoxin Production in Transgenic Maize Expressing the α-amylase Inhibitor from Lablab purpureus L.

Published on: February 15, 2019

11.0K
Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles
10:51

Customization of Aspergillus niger Morphology Through Addition of Talc Micro Particles

Published on: March 15, 2012

19.7K
Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software
11:30

Quantitative Analysis of Aspergillus nidulans Growth Rate using Live Microscopy and Open-Source Software

Published on: July 24, 2021

4.2K

科学领域:

  • 生物技术是生物技术.
  • 生物工艺工程 生物工艺工程
  • 菌类学 菌类学是指菌类学.

背景情况:

  • 迷幻中的一种化合物psilocybin在治疗精神疾病方面表现有前途.
  • 目前用于临床研究的psilocybin供应依赖于化学合成.
  • 需要一种生物技术生产路线来满足不断增长的需求.

研究的目的:

  • 开发一种高效的生物技术工艺,用于使用阿斯伯吉路斯尼杜兰斯 (Aspergillus nidulans) 制造西宾.
  • 为了优化种植条件,为高产量西合成.
  • 为了证明生物工艺的可扩展性和稳定性.

主要方法:

  • 利用过度生产的阿斯伯吉卢斯尼杜兰斯菌株进行了西宾生物合成.
  • 描述和优化摇动瓶培养,重点关注风湿学,氧气和输入功率.
  • 将生物工艺扩展到一个7L的水箱反应堆,管理粘度和氧气转移.
  • 采用压力反应器来增强粘性培养中的氧气供应.
  • 补充硫酸以克服蛋白质生物合成的限.

主要成果:

  • 实现了一种强大而高效的批量生物工艺,用于生产西宾.
  • 在68小时内从葡萄糖中产生了542mg/L的psilocybin.
  • 从震动瓶成功扩展到7L反应堆.
  • 验证了压力生物工艺对氧气有限的丝状培养物的有效性.

结论:

  • 成功开发了一种可扩展和高效的生物技术工艺,用于生产西宾.
  • 这种方法为制药应用提供了潜在的可持续供应.
  • 压力生物反应器适合培养像阿斯伯吉路斯尼杜兰斯这样的剪切敏感的丝状生物.