以为动力的益生菌通过生物膜转化重新配置肠道
Yonglu Li1,2,3, Shihai Yan1,2,3, Hongdi Song1,2,3
1School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|December 30, 2025
概括
一种新的基于的益生菌策略修改了Lactiplantibacillus (Lap) 来对抗炎症性肠病 (IBD) 中的Desulfovibrio (Des) 过度生长. 这种方法重新配置肠道环境,增强殖民抵抗力,以有效治疗IBD.
科学领域:
- 微生物学 微生物学
- 胃肠病学 胃肠病学
- 生物技术是生物技术.
背景情况:
- 过度的Desulfovibrio (Des) 形成生物膜,导致炎症性肠病 (IBD) 的炎症.
- 由Des创建的有利于病原体的微环境通过阻碍殖民抵抗来阻碍益生菌的有效性.
- 恢复肠道平衡对于管理IBD和改善益生菌功能至关重要.
研究的目的:
- 开发一个改进的益生菌平台,Ca2+/KAE@Lap,用于肠道的重新配置.
- 针对IBD中非介导的殖民抵抗机制.
- 提高益生菌在肠道中的殖民和有效性.
主要方法:
- 益生菌Lactiplantibacillus (Lap) 经过离子 (Ca2+) 和kaempferol-3-O-rutinoside (KAE) 的修饰.
- 评估了Ca2+/KAE@Lap平台对其破坏Des生物膜和恢复肠道平衡的能力.
- 研究了包括界面结合,杀菌活性,调节和上皮细胞修复在内的机制.
主要成果:
- 在Ca2+/KAE@Lap平台上展示了Ca2+桥接的界面结合和针对Des的定向杀菌活性.
- 这导致了细菌的替代,恢复平衡,并恢复上皮质能量代谢和粘液层.
- 生物膜组成从DES主导转变为拉普丰富,表明殖民抵抗的重定向.
结论:
- 基于的生物膜转化策略有效地破坏了无介导的殖民抵抗.
- Ca2+/KAE@Lap通过促进持续的殖民和有利的利基竞争,克服了传统益生菌的局限性.
- 这种方法通过调节肠道微生物群并恢复宿主-病原体平衡,为IBD治疗提供了一个有希望的治疗策略.
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